Speedy E5 Activators
Speedy E5 Activators are a collection of chemical compounds that indirectly influence the functional activity of Speedy E5 through diverse signaling mechanisms. Forskolin, by increasing cAMP levels, activates PKA, which can phosphorylate various substrates and potentially enhance the activity of Speedy E5 in cell cycle progression. Additionally, EGCG inhibits multiple protein kinases, possibly activating compensatory signaling that upregulates Speedy E5's role in proliferation. S1P, by activating its receptors, can initiate signaling cascades that involve PI3K/Akt and thus may enhance Speedy E5 activity related to cell survival. PMA, through PKC activation, and ionomycin, by raising calcium levels, both potentially augment Speedy E5 activity by influencing phosphorylation events and calcium-sensitive signaling respectively. LY294002 and Wortmannin, as PI3K inhibitors, and U0126, as a MEK inhibitor, could indirectly activate alternative pathways that result in the enhanced activity of Speedy E5, particularly in its regulatory capacity in the cell cycle.
Furthermore, SB203580's inhibition of p38 MAPK and A23187's role as a calcium ionophore suggest the potential for alternative signaling pathways to be activated, leading to an increase in Speedy E5 activity. Staurosporine, despite its broad kinase inhibition, might selectively activate Speedy E5-involved pathways, thereby promoting its role in managing cell cycle checkpoints. Rapamycin's inhibition of mTOR may also lead to the compensatory activation of pathways that enhance Speedy E5 activity, especially regarding cell growth. Collectively, these chemicals, through theirspecific influence on cellular pathways, serve to enhance the functional activity of Speedy E5, ensuring that its involvement in critical cell cycle events is optimized without the necessity for direct activation or upregulation of expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which subsequently activates protein kinase A (PKA). PKA phosphorylation can lead to changes in the function and activity of Speedy E5, enhancing its role in cell cycle progression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases, which may result in the activation of compensatory pathways that upregulate the activity of Speedy E5, thereby promoting its role in cellular signaling related to proliferation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its receptors, initiating signaling cascades that can include the activation of phosphoinositide 3-kinase (PI3K) and Akt, leading to cellular processes that potentially enhance the activity of Speedy E5 in cell survival and proliferation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent signaling pathways, possibly increasing the activity of Speedy E5 through modulation of calcium-sensitive cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate targets that modulate the activity of Speedy E5, leading to enhanced cell cycle progression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, alters downstream signaling that may result in the compensatory activation of pathways involving Speedy E5, thereby enhancing its cellular role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which may shift the signaling balance, allowing for the activation of alternative pathways that could enhance the activity of Speedy E5 in cell cycle regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially leading to the activation of alternative signaling pathways that may enhance the activity of Speedy E5, influencing cell cycle and stress response. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, raising intracellular calcium levels and possibly activating calcium-dependent signaling cascades that increase the activity of Speedy E5. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a protein kinase inhibitor that, through its broad-spectrum activity, may preferentially activate signaling pathways involving Speedy E5, thereby enhancing its role in cell cycle checkpoints. | ||||||