Speedy E5 Inhibitors
Speedy E5 Inhibitors belongs to a category of compounds that specifically target and interact with the Speedy E5 enzyme. This enzyme, a vital component in cellular processes, plays a crucial role in regulating certain biochemical pathways. Speedy E5 Inhibitors are characterized by their ability to bind to the active site of the Speedy E5 enzyme, thereby modulating its activity. The molecular structure of these inhibitors is meticulously designed to fit into the enzyme's active site, forming a stable complex that interferes with the normal catalytic function of Speedy E5.
The mechanism of action involves the formation of non-covalent bonds between the inhibitor and specific residues within the enzyme's active site. This binding event induces conformational changes in the enzyme, preventing its substrate from accessing the catalytic site and, consequently, hindering the enzymatic reaction. The development of Speedy E5 Inhibitors is a result of advanced medicinal chemistry and molecular modeling techniques, aiming to fine-tune the interaction between the inhibitor and the target enzyme for optimal efficacy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor ZM447439 targets Aurora B kinase, which is crucial for the regulation of Speedy E5 by ensuring proper mitotic entry and exit. Inhibition of Aurora B kinase leads to the destabilization of Speedy E5's function in cell cycle progression. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
VX-680 is an inhibitor of Aurora kinases. It impedes Aurora A kinase activity, which is important for the centrosome maturation and separation that influences Speedy E5's role in cell cycle control. Its inhibition can indirectly disrupt Speedy E5's function in spindle assembly and stability. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI-2536 is a Plk1 inhibitor that disrupts polo-like kinase 1, which is involved in multiple stages of mitosis. Since Speedy E5 is implicated in cell cycle regulation, inhibiting Plk1 can lead to the impairment of Speedy E5's associated mitotic functions. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, disrupting mitotic spindle function. This can indirectly inhibit Speedy E5 by arresting cells in the G2/M phase, where Speedy E5 is actively involved in the progression of the cell cycle. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Cyclin-dependent kinase inhibitor Roscovitine impairs CDK1, CDK2, CDK5, and CDK9. Speedy E5's function is related to CDKs' activity during the cell cycle, and thus Roscovitine can indirectly inhibit Speedy E5 function by blocking CDK activity essential for cell cycle transitions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor SP600125 interferes with the JNK signaling pathway, which can be involved in cellular proliferation and apoptosis. JNK pathway inhibition can result in altered cell cycle progression where Speedy E5 has a role, thereby indirectly inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which may affect the cell cycle and inflammatory response pathways. Inhibition of p38 MAPK can indirectly affect Speedy E5 function by altering the cellular stress response and cell cycle arrest mechanisms in which Speedy E5 is implicated. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which acts upstream of ERK in the MAPK pathway. Speedy E5, being part of the cell cycle regulatory network, can be indirectly influenced by the modulation of ERK activity, which is essential for cell proliferation and growth signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that affects the PI3K/Akt signaling pathway, which is critical for cell survival and growth. By inhibiting this pathway, LY294002 can indirectly reduce Speedy E5's activity, as PI3K/Akt can be implicated in the same cell cycle processes as Speedy E5. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and mTOR signaling is important for cell growth, proliferation, and survival. Inhibiting mTOR can influence Speedy E5 indirectly by affecting the protein synthesis and cell growth pathways that Speedy E5 may be involved in. | ||||||