Speedy C Activators
Speedy C Activators are a class of chemicals that enhance the functional activity of Speedy C via distinct pathways. Phorbol 12-myristate 13-acetate (PMA) activates PKC, leading to the phosphorylation of Speedy C and enhancing its activity. Forskolin, IBMX, Epinephrine, Prostaglandin E2, Isoproterenol, Dibutyryl-cAMP, and Rolipram all work by activating adenylyl cyclase, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate Speedy C.
Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, maintaining the phosphorylation state of Speedy C, thus enhancing its activity. Staurosporine at low concentrations preferentially inhibits protein phosphatases, enhancing the phosphorylation and activity of Speedy C. H-89, at higher concentrations inhibits other kinases, leading to a net increase in the phosphorylation and activity of Speedy C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC activation leads to the phosphorylation of Speedy C, thereby enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can activate Protein Kinase A (PKA), which can phosphorylate and activate Speedy C. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Okadaic Acid maintains the phosphorylation state of Speedy C, thus enhancing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits PP1 and PP2A, enhancing the phosphorylation and activity of Speedy C. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, leading to increased cAMP levels. The elevated cAMP can activate PKA, which in turn phosphorylates and activates Speedy C. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, a hormone and neurotransmitter, activates adenylyl cyclase via G protein-coupled receptors. This increases cAMP levels, leading to activation of PKA and subsequent activation of Speedy C. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G protein-coupled receptor, leading to activation of adenylyl cyclase, an increase in cAMP levels, and subsequent activation of Speedy C via PKA. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates adenylyl cyclase, leading to increased cAMP levels, PKA activation, and subsequent activation of Speedy C. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA, leading to phosphorylation and activation of Speedy C. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. However, at low concentrations, it preferentially inhibits protein phosphatases, thereby enhancing the phosphorylation and activity of Speedy C. | ||||||