Spc25 Activators
Spc25 Activators encompasses chemicals that can indirectly influence the activity of Spc25 by affecting cell cycle progression and the processes of mitosis. These chemicals include nocodazole and taxol, which disrupt the normal dynamics of microtubules, leading to potential changes in Spc25 activity as the cell attempts to correct errors in spindle assembly. BI 2536, RO-3306, AZ3146, and Roscovitine inhibit key kinases involved in cell cycle control and spindle assembly checkpoint regulation, such as Plk1, CDK1, Mps1, and other CDKs. These inhibitors can alter the normal progression of the cell cycle and the function of the spindle assembly checkpoint, which can indirectly lead to modulation of Spc25 activity.
Another group of chemicals in the Spc25 Activators class includes S-Trityl-L-cysteine, Monastrol, Purvalanol A, ZM-447439, Hesperadin, and Tozasertib. These compounds inhibit proteins essential for spindle formation (Eg5) and the function of the spindle assembly checkpoint(Aurora kinases). Inhibition of these proteins can lead to defective spindle assembly and spindle checkpoint signaling, potentially influencing Spc25 activity. S-Trityl-L-cysteine and Monastrol act on Eg5, a motor protein required for bipolar spindle formation. Inhibition of Eg5 can disrupt spindle formation, leading to an indirect effect on Spc25 activity as the cell tries to correct spindle assembly. Purvalanol A, like the previously mentioned CDK inhibitors, can disrupt cell cycle progression, leading to potential changes in Spc25 activity. ZM-447439, Hesperadin, and Tozasertib, on the other hand, inhibit Aurora kinases, proteins that play a crucial role in spindle assembly and the correction of kinetochore-microtubule attachments. Aurora kinase inhibition can lead to defects in these processes, potentially affecting Spc25 activity as part of the spindle assembly checkpoint.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole depolymerizes microtubules, disrupting mitotic progression. This stalling of the cell cycle can lead to increased demand for Spc25 as the cell attempts to correct spindle assembly errors. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, preventing their depolymerization. This can lead to aberrant mitotic spindles, potentially increasing the demand for Spc25 in spindle checkpoint signalling. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a potent Polo-like kinase 1 (Plk1) inhibitor. Plk1 is involved in regulating the spindle assembly checkpoint, a process that requires Spc25. Inhibition of Plk1 can indirectly affect Spc25 activity. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
RO-3306 is a selective inhibitor of cyclin-dependent kinase 1 (CDK1), which is crucial for cell cycle progression. Inhibition of CDK1 can lead to cell cycle arrest, potentially affecting Spc25 activity. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $218.00 $905.00 | 7 | |
AZ3146 is a potent and selective inhibitor of the mitotic kinase Mps1. Mps1 inhibition can disrupt the spindle assembly checkpoint, potentially influencing Spc25 activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a selective inhibitor of CDKs, including CDK1, CDK2, and CDK5. These kinases are essential for cell cycle progression, and their inhibition can indirectly influence Spc25 activity. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5, a motor protein required for bipolar spindle formation. Inhibition of Eg5 can disrupt spindle assembly, potentially leading to changes in Spc25 activity. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a potent inhibitor of the kinesin Eg5. Like S-Trityl-L-cysteine, it disrupts spindle formation, which can indirectly affect Spc25 activity. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a potent CDK inhibitor. By inhibiting CDKs, Purvalanol A can disrupt cell cycle progression, potentially influencing Spc25 activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is a selective inhibitor of Aurora kinases, which are essential for proper spindle assembly. Inhibition of Aurora kinases can disrupt the spindle assembly checkpoint, potentially influencing Spc25 activity. | ||||||