SPATA6 Activators
SPATA6 activators are a collection of chemicals that can directly or indirectly enhance the functionality of SPATA6, a protein that contributes to various biological processes. The activators achieve this through manipulation of specific signaling pathways and cellular processes that SPATA6 is directly involved in. Some of these activators function by directly increasing intracellular levels of cyclic AMP or calcium ions. For instance, Forskolin and Isoprenaline elevate cyclic AMP levels, which can consequently lead to SPATA6 activation. Similarly, Ionomycin and A23187, by raising intracellular calcium levels, could trigger SPATA6 activation.
On the other hand, there are activators that work indirectly by inhibiting protein phosphatases, thereby promoting protein phosphorylation, which could lead to SPATA6 activation. Okadaic Acid and Calyculin A are examples of such compounds that inhibit protein phosphatases like PP1 and PP2A. Other chemicals like EGCG, Staurosporine, Bisindolylmaleimide I, LY294002, and PD98059 influence various signaling pathways, and could indirectly influence SPATA6 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that directly activates adenylyl cyclase, leading to increased levels of cyclic AMP. SPATA6 activity might be enhanced as cyclic AMP acts as a second messenger in various cellular pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is an ionophore that selectively binds to calcium ions, leading to an increase in intracellular calcium levels. This can trigger signaling events that enhance SPATA6 activity, given the protein's involvement in calcium-dependent processes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to enhanced protein phosphorylation. This can boost SPATA6 activity if the protein's functionality involves phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like Okadaic Acid, inhibits protein phosphatases PP1 and PP2A, promoting phosphorylation processes that could enhance SPATA6 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC), which could phosphorylate and activate SPATA6, assuming the protein's activity involves PKC-responsive pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoprenaline is a beta-adrenergic agonist that increases intracellular levels of cyclic AMP, which could enhance SPATA6 activity if the protein is involved in cyclic AMP-dependent pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ion carrier that transports calcium ions, leading to increased intracellular calcium levels. This can enhance SPATA6 activity if the protein's functionality involves calcium-dependent processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea that can influence various signaling pathways. This could enhance SPATA6 activity if those pathways are directly involved in the protein's functionality. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which may lead to the activation of SPATA6 if it's regulated by these enzymes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
This compound is a potent and selective inhibitor of PKC, which could potentially enhance the activity of SPATA6 if it's regulated by PKC-dependent pathways. | ||||||