SPATA6 Inhibitors
Chemical inhibitors of SPATA6 target the protein's reliance on microtubule dynamics, essential for its function in spermatogenesis. Paclitaxel (Taxol), a well-known microtubule stabilizer, inhibits the disassembly of microtubules, a process SPATA6 requires for its role in sperm cell development. Similarly, Eribulin's selective inhibition of microtubule growth prevents the proper formation of these structures, disrupting SPATA6's functionality. Vinblastine and Vincristine bind to tubulin, the building block of microtubules, preventing their polymerization and effectively hindering the function of SPATA6 in the testes. Colchicine's binding to tubulin also inhibits polymerization into microtubules, a necessary step for cell division and intracellular transport, processes in which SPATA6 is implicated.
Further disrupting microtubule assembly, Podophyllotoxin, Griseofulvin, Thiabendazole, and Vinorelbine bind to tubulin and prevent its polymerization, which is crucial for the function of SPATA6 during sperm formation. Nocodazole, on the other hand, destabilizes microtubules, leading to the inhibition of SPATA6, which depends on intact microtubule networks. The action of Peloruside A in stabilizing microtubules and preventing their depolymerization can inhibit SPATA6 by disrupting the dynamic balance essential for its function. Halichondrin B, as a potent microtubule destabilizing agent, similarly affects the microtubule dynamics, a critical factor for the functional expression of SPATA6 during the development of sperm cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is essential for cell division and many other cellular processes. As SPATA6 is involved in sperm cell development, microtubule stabilization can disrupt the proper function of SPATA6, leading to inhibited sperm cell formation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. As SPATA6 is implicated in microtubule-related processes during spermatogenesis, the inhibition of microtubule polymerization can disrupt SPATA6 function, leading to inhibited sperm cell development. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, which are crucial for cell division and intracellular transport. Through this action, it can inhibit the normal functioning of SPATA6 by disrupting the cytoskeletal dynamics needed for its role in spermatogenesis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. By destabilizing microtubules, it can inhibit SPATA6 function as it relies on intact microtubule networks for its role in testicular development and sperm formation. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly. By targeting microtubule dynamics, it can inhibit SPATA6 function, as SPATA6 is necessary for microtubule-dependent processes in the formation of sperm. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin. This inhibition of microtubule dynamics can interfere with SPATA6's role in spermatogenesis, as the protein relies on microtubule structures for its function. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase. This selective inhibition of microtubule dynamics can impede the function of SPATA6 in spermatogenesis, as it is dependent on proper microtubule formation. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. This disruption of microtubule assembly is likely to inhibit SPATA6 activity, which is involved in microtubule-based processes within the testes. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $28.00 $79.00 $255.00 $775.00 $1938.00 | ||
Vinorelbine binds to tubulin and inhibits microtubule formation. By disrupting microtubule dynamics, it can inhibit the function of SPATA6, as SPATA6 is likely involved in microtubule-based mechanisms necessary for spermatogenesis. | ||||||