Sp9 Inhibitors
Sp9 inhibitors encompass a diverse range of compounds primarily centered around influencing the protein's ability to bind DNA and initiate transcription. The compounds can be broadly classified into those that interfere with the epigenetic state of the DNA, and those that target the reading of these epigenetic marks. Agents like Decitabine and 5-aza-2'-deoxycytidine alter the methylation state of DNA, which can directly impact the ability of Sp9 to bind to its target genes. On the other hand, compounds like JQ1 and PFI-1 are bromodomain inhibitors that interfere with the reading of acetylation marks on histones, which can indirectly influence Sp9's access to its target genes.
Moreover, the chromatin state (how DNA is packed around histones) plays a crucial role in Sp9's ability to access its target genes. Agents like BIX-01294, M344, and UNC0638 are designed to influence this chromatin state by targeting various enzymes responsible for adding or removing chemical marks on histones. These chemical modifications on histones can either encourage or discourage Sp9 from binding to certain regions of DNA.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Decitabine | 22432-95-7 | sc-500301 sc-500301A | 10 mg 100 mg | $347.00 $2448.00 | ||
Demethylating agent that can potentially affect Sp9's ability to bind DNA by changing methylation patterns. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
A bromodomain inhibitor that can affect the reading of acetylation marks on histones, possibly impacting Sp9's access to DNA. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
A G9a histone methyltransferase inhibitor which might alter the chromatin state, affecting Sp9 binding. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
DNA methyltransferase inhibitor that can change DNA methylation, potentially affecting Sp9's DNA binding. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $107.00 $316.00 | 8 | |
HDAC inhibitor which can modify the histone acetylation state, possibly affecting Sp9's transcriptional activity. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $96.00 | ||
Another bromodomain inhibitor; it can affect the reading of histone acetylation marks. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
An inhibitor of G9a histone methyltransferase, affecting chromatin states. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Bromodomain inhibitor that can potentially interfere with Sp9's associated factors. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
DOT1L inhibitor that affects histone methylation, potentially affecting Sp9's transcriptional activity. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
DNA methyltransferase inhibitor, could affect Sp9's DNA-binding affinity. | ||||||