Molecular structure of α-Decitabine, CAS Number: 22432-95-7
α-Decitabine (CAS 22432-95-7)
Alternate Names:
1-(2-Deoxy-α-D-ribofuranosyl)-5-azacytosine; NSC 127717; 4-Amino-1-(2-deoxy-α-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one
CAS Number:
22432-95-7
Molecular Weight:
228.21
Molecular Formula:
C8H12N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-Decitabine is a chemical of interest in the field of molecular genetics for studying epigenetic modifications and gene expression regulation. As an analogue of cytidine, it is embedded to investigate the mechanisms of DNA methylation, a key process that affects gene activity without altering the DNA sequence itself. In some studies, α-Decitabine is utilized to explore the effects of DNA methylation inhibitors on gene expression, providing insights into how epigenetic changes can influence cellular differentiation and function. α-Decitabine is also useful for studying of epigenetic markers for various biological processes and the potential reversibility of epigenetic states.
α-Decitabine (CAS 22432-95-7) References
- Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-methyl-2'-deoxycytidine. | Roosendaal, J., et al. 2019. J Pharm Biomed Anal. 164: 16-26. PMID: 30366147
- Is Monitoring of the Intracellular Active Metabolite Levels of Nucleobase and Nucleoside Analogs Ready for Precision Medicine Applications? | Huang, S., et al. 2022. Eur J Drug Metab Pharmacokinet. 47: 761-775. PMID: 35915365
Inhibitor of:
dCK, and Sp9.Activator of:
u4/u6 snRNP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Decitabine, 10 mg | sc-500301 | 10 mg | $347.00 | |||
α-Decitabine, 100 mg | sc-500301A | 100 mg | $2448.00 |