SP-A1 Inhibitors
SP-A1 Inhibitors refer to a class of chemical compounds designed to target and modulate the activity of surfactant protein A1 (SP-A1). Surfactant proteins are essential components of the pulmonary surfactant, a complex mixture found in the alveoli of the lungs. They play a crucial role in maintaining the surface tension within the alveoli and preventing their collapse during respiration. SP-A1 is a specific isoform of surfactant protein A (SP-A) and is known for its involvement in the innate immune response and the regulation of lung function.
These inhibitors are designed with the aim of regulating the function of SP-A1 by binding to it and altering its activity in various ways. They are often used as research tools to study the specific functions of SP-A1 in lung biology and host defense mechanisms. By inhibiting SP-A1, researchers can gain insights into its role in various physiological and pathological processes, including lung infections, inflammatory responses, and respiratory disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can modulate gene expression. It might inhibit SP-A1 expression by influencing transcription factors or signaling pathways associated with inflammation and immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, found in green tea, has been studied for its ability to modulate various cellular pathways. It could potentially downregulate SP-A1 expression by interfering with inflammatory signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a role in cell differentiation and proliferation. It could alter SP-A1 expression levels by modulating nuclear receptors and transcription factors involved in lung development. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, from turmeric, has anti-inflammatory properties. It might influence SP-A1 expression through its ability to modulate NF-κB and other signaling pathways associated with inflammation and immune responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes, has antioxidant properties and could affect SP-A1 expression by modulating redox-sensitive signaling pathways and transcription factors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, activates the Nrf2 pathway, potentially leading to changes in the expression of proteins involved in immune responses, including SP-A1. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine has immunomodulatory effects and might alter SP-A1 expression by influencing endosomal pH and interfering with cellular signaling involved in the immune response. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is a compound that can induce certain liver enzymes, potentially affecting the metabolism and activity of molecules involved in the regulation of SP-A1 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It could potentially inhibit SP-A1 expression by modulating signaling pathways and transcription factors involved in inflammation and immune responses. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione has antimicrobial properties and may influence the expression of various proteins, including SP-A1, though the exact mechanism of its action on SP-A1 expression requires further investigation. | ||||||