SON Activators
SON Activators are a class of chemicals that enhance the functional activity of SON via distinct pathways. Phorbol 12-myristate 13-acetate (PMA) activates PKC, leading to the phosphorylation of SON and enhancing its activity. Forskolin, IBMX, Epinephrine, Prostaglandin E2, Isoproterenol, Dibutyryl-cAMP, and Rolipram all work by activating adenylyl cyclase, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate SON.
Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, maintaining the phosphorylation state of SON, thus enhancing its activity. Staurosporine, although a broad-spectrum protein kinase inhibitor, at low concentrations preferentially inhibits protein phosphatases, enhancing the phosphorylation and activity of SON. H-89 at higher concentrations inhibits other kinases, leading to a net increase in the phosphorylation and activity of SON.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC activation leads to the phosphorylation of various proteins, including SON, thereby enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can activate Protein Kinase A (PKA), which can phosphorylate and activate SON. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Okadaic Acid maintains the phosphorylation state of SON, thus enhancing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits PP1 and PP2A, enhancing the phosphorylation and activity of SON. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, leading to increased cAMP levels. The elevated cAMP can activate PKA, which in turn phosphorylates and activates SON. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that activates adenylyl cyclase via G protein-coupled receptors. This increases cAMP levels, leading to activation of PKA and subsequent activation of SON. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G protein-coupled receptor, leading to activation of adenylyl cyclase, an increase in cAMP levels, and subsequent activation of SON via PKA. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates adenylyl cyclase, leading to increased cAMP levels, PKA activation, and subsequent activation of SON. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA, leading to phosphorylation and activation of SON. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. However, at low concentrations, it preferentially inhibits protein phosphatases, thereby enhancing the phosphorylation and activity of SON. | ||||||