SON Activators
SON Activators are a class of chemicals that enhance the functional activity of SON via distinct pathways. Phorbol 12-myristate 13-acetate (PMA) activates PKC, leading to the phosphorylation of SON and enhancing its activity. Forskolin, IBMX, Epinephrine, Prostaglandin E2, Isoproterenol, Dibutyryl-cAMP, and Rolipram all work by activating adenylyl cyclase, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate SON.
Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, maintaining the phosphorylation state of SON, thus enhancing its activity. Staurosporine, although a broad-spectrum protein kinase inhibitor, at low concentrations preferentially inhibits protein phosphatases, enhancing the phosphorylation and activity of SON. H-89 at higher concentrations inhibits other kinases, leading to a net increase in the phosphorylation and activity of SON.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, leading to increased cAMP levels. The elevated cAMP can activate PKA, which in turn phosphorylates and activates SON. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent inhibitor of PKA. However, at higher concentrations, it inhibits other kinases, leading to a net increase in the phosphorylation and activity of SON. | ||||||