Sodium Channel Modulators
Items 41 to 50 of 73 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
QX 222 | 21236-55-5 | sc-203673 sc-203673A | 10 mg 50 mg | $50.00 $230.00 | ||
QX 222 functions as a sodium channel modulator by selectively interacting with the channel's voltage-sensing domains, stabilizing the inactivated state and reducing sodium ion permeability. Its unique structure promotes a rapid onset of action, allowing for swift modulation of channel activity. The compound exhibits a distinct affinity for specific channel subtypes, leading to differential effects on neuronal excitability and synaptic transmission. This specificity enhances its potential for targeted modulation of electrical signaling. | ||||||
Ambroxol hydrochloride | 23828-92-4 | sc-200816 | 1 g | $54.00 | ||
Ambroxol hydrochloride acts as a sodium channel modulator by engaging with the channel's gating mechanisms, influencing the conformational states of the protein. Its unique molecular interactions facilitate a nuanced alteration in ion flow, promoting a selective inhibition of sodium currents. This compound demonstrates a distinctive kinetic profile, allowing for a gradual modulation of channel activity, which can lead to varied effects on cellular excitability and signaling pathways. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Icilin functions as a sodium channel modulator by selectively binding to specific sites on the channel, altering its permeability to sodium ions. This compound exhibits unique interaction dynamics, stabilizing certain conformations that influence channel activation and inactivation rates. Its distinct reaction kinetics allow for rapid modulation of ion flux, impacting neuronal excitability and synaptic transmission. The compound's ability to fine-tune channel behavior underscores its role in cellular signaling mechanisms. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine acts as a sodium channel modulator by engaging with the channel's lipid bilayer environment, influencing its structural dynamics. This compound exhibits a unique ability to alter the gating kinetics of sodium channels, enhancing their responsiveness to stimuli. Its interactions can lead to a shift in the voltage-dependence of activation, thereby affecting the overall ionic balance within cells. The modulation of these channels contributes to intricate signaling pathways, showcasing Vinpocetine's role in cellular communication. | ||||||
Deltamethrin | 52918-63-5 | sc-24013 sc-24013A | 10 mg 50 mg | $62.00 $259.00 | 8 | |
Deltamethrin functions as a sodium channel modulator by binding to specific sites within the channel, leading to prolonged opening and increased ion permeability. This compound exhibits a distinct mechanism of action, characterized by its ability to stabilize the inactivated state of sodium channels, thereby disrupting normal excitability. Its interactions can result in altered action potential propagation, influencing neuronal and muscular signaling pathways, and highlighting its complex role in cellular excitability. | ||||||
Flecainide acetate | 54143-56-5 | sc-203581 sc-203581A | 10 mg 50 mg | $60.00 $209.00 | ||
Flecainide acetate acts as a sodium channel modulator by selectively interacting with the channel's voltage-sensing domains, leading to a unique alteration in gating kinetics. This compound preferentially binds to the inactivated state of sodium channels, effectively slowing their recovery and prolonging the refractory period. Its distinct binding affinity influences the overall excitability of cardiac tissues, showcasing its intricate role in modulating ionic currents and cellular signaling dynamics. | ||||||
Tocainide hydrochloride | 71395-14-7 | sc-253706 | 10 mg | $128.00 | ||
Tocainide hydrochloride acts as a sodium channel modulator by selectively binding to the channel's voltage-sensing domains, altering the conformational state of the protein. This interaction enhances the channel's inactivation kinetics, leading to a reduction in sodium ion permeability during depolarization. The compound's unique ability to fine-tune channel responsiveness contributes to the regulation of excitatory signaling, impacting cellular excitability and ionic equilibrium. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
Lamotrigine functions as a sodium channel modulator by stabilizing the inactive state of the channel, effectively reducing its availability for activation. This modulation occurs through specific interactions with the channel's pore region, influencing the gating kinetics. The compound exhibits a unique ability to preferentially inhibit high-frequency firing of action potentials, thereby altering neuronal excitability and contributing to the dynamic balance of ion flow across membranes. | ||||||
5-(N-Methyl-N-isobutyl)-Amiloride | 96861-65-3 | sc-202929 sc-202929A | 5 mg 25 mg | $82.00 $189.00 | ||
5-(N-Methyl-N-isobutyl)-Amiloride acts as a sodium channel modulator by selectively binding to the channel's extracellular domain, leading to a conformational change that decreases sodium ion permeability. This compound exhibits a distinct mechanism of action by disrupting the electrochemical gradient, which influences the channel's activation threshold. Its unique structural features allow for targeted interactions that fine-tune ion channel dynamics, impacting cellular excitability and signaling pathways. | ||||||
SDZ-201106 (±), (DPI-201106) | 97730-95-5 | sc-201072 sc-201072A sc-201072B | 25 mg 100 mg 250 mg | $67.00 $217.00 $490.00 | 2 | |
SDZ-201106 (±), also known as DPI-201106, functions as a sodium channel modulator through its ability to interact with specific binding sites on the channel protein. This interaction stabilizes certain conformations, effectively altering the channel's gating kinetics. The compound's unique molecular architecture facilitates selective engagement with the channel, influencing ion flow and contributing to the modulation of excitatory signals in cellular environments. Its distinct binding affinity enhances the precision of sodium ion regulation. | ||||||