Date published: 2025-9-27

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QX 222 (CAS 21236-55-5)

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Alternate Names:
2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium chloride
Application:
QX 222 is a Na+ channel blocker
CAS Number:
21236-55-5
Molecular Weight:
256.77
Molecular Formula:
C13H21N2O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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QX 222 is a chemical that functions as a fluorescent dye in research and development settings. It is used to label and visualize cellular structures and molecules due to its ability to emit a bright and stable fluorescence when excited by specific wavelengths of light. This allows scientists to track and study the movement and localization of various cellular components in real-time. QX 222 achieves this by binding to specific targets within the cell, such as proteins or nucleic acids, and emitting light upon excitation, enabling researchers to observe and analyze the dynamics of these targets within the cellular environment. Its mode of action involves interacting with the cellular components of interest, leading to the emission of fluorescence that can be visualized and quantified using microscopy and imaging techniques. This enables scientists to gain insights into the behavior and function of these cellular components, contributing to the advancement of knowledge in various fields of biological and biomedical research.


QX 222 (CAS 21236-55-5) References

  1. A voltage-clamp study of the effect of two lidocaine derivatives on the time course of end-plate currents.  |  Beam, KG. 1976. J Physiol. 258: 279-300. PMID: 1085354
  2. The voltage dependence of recovery from use-dependent block by QX-222 separates mechanisms for drug egress in the cardiac sodium channel.  |  Lardin, HA. and Lee, PJ. 2006. Biochem Pharmacol. 71: 1299-1307. PMID: 16637111
  3. Reverse pharmacology of the nicotinic acetylcholine receptor. Mapping the local anesthetic binding site.  |  Leonard, RJ., et al. 1991. Ann N Y Acad Sci. 625: 588-99. PMID: 2058913
  4. Coapplication of lidocaine and membrane-impermeable lidocaine derivative QX-222 produces divergent effects on evoked and spontaneous nociceptive behaviors in mice.  |  Hu, SP., et al. 2014. Biomed Res Int. 2014: 628729. PMID: 25506595
  5. Attenuation of glutamate-action, excitatory postsynaptic potentials, and spikes by intracellular QX 222 in hippocampal neurons.  |  Puil, E. and Carlen, PL. 1984. Neuroscience. 11: 389-98. PMID: 6144079
  6. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222.  |  Flatman, JA., et al. 1982. J Neurophysiol. 48: 419-30. PMID: 6288888
  7. Cooperative interactions between general anesthetics and QX-222 within the pore of the acetylcholine receptor ion channel.  |  Dilger, JP. and Vidal, AM. 1994. Mol Pharmacol. 46: 169-75. PMID: 7520126
  8. Blockade of lysophosphatidylcholine-modified cardiac Na channels by a lidocaine derivative QX-222.  |  Undrovinas, AI. and Makielski, JC. 1996. Am J Physiol. 271: H790-7. PMID: 8770124
  9. Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor.  |  Arias, HR. 1996. Mol Membr Biol. 13: 1-17. PMID: 9147657
  10. Topology of ligand binding sites on the nicotinic acetylcholine receptor.  |  Arias, HR. 1997. Brain Res Brain Res Rev. 25: 133-91. PMID: 9403137
  11. Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor.  |  Arias, HR. 1998. Biochim Biophys Acta. 1376: 173-220. PMID: 9748559

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

QX 222, 10 mg

sc-203673
10 mg
$50.00

QX 222, 50 mg

sc-203673A
50 mg
$230.00