Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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Application: An expectorant antioxidant and antiinflammatory agent
CAS Number: 23828-92-4
Purity: 98%
Molecular Weight: 414.6
Molecular Formula: C13H18Br2N2O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


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Appearance :
Crystalline powder
Physical State :
Solubility :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
Storage :
Store at 4° C
Melting Point :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
pK Values :
pKb: 8.69
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 386
MDL Number :
EC Number :

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Certificate of Analysis

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upto what temperature can amboxol hydrochloride be subjected before it degrade

Asked by: chandrasekarn
Thank you for your question. Unfortunately this has not been tested. We recommend storing at room temperature and will be stable at that temperature. The melting point is 233-234ºC.
Answered by: Technical Support
Date published: 2018-09-20
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