Molecular structure of Ambroxol hydrochloride, CAS Number: 23828-92-4
Ambroxol hydrochloride (CAS 23828-92-4)
Application:
Ambroxol hydrochloride is an expectorant antioxidant and antiinflammatory agent
CAS Number:
23828-92-4
Purity:
98%
Molecular Weight:
414.6
Molecular Formula:
C13H18Br2N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ambroxol hydrochloride is a compound extensively studied in the context of biological research, particularly in areas concerning its mucolytic properties and effects on mucus clearance. In laboratory studies, it is often used to investigate the regulation of mucus secretion and the modulation of surfactant production in respiratory cells. Researchers also utilize ambroxol hydrochloride to explore its impact on cellular antioxidant defense mechanisms, as it has shown to influence the expression of certain genes related to antioxidative enzymes. Moreover, the compound is of interest in the study of ion transport across epithelial surfaces, which is essential for maintaining proper pulmonary function.
Ambroxol hydrochloride (CAS 23828-92-4) References
- Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. | Gibbs, BF., et al. 1999. Inflamm Res. 48: 86-93. PMID: 10202994
- Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. | Su, X., et al. 2004. Intensive Care Med. 30: 133-40. PMID: 14504727
- Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis. | Laurent, A., et al. 2004. Hepatology. 39: 1277-85. PMID: 15122756
- In vitro and in vivo antioxidant activity of ambroxol. | Stetinová, V., et al. 2004. Clin Exp Med. 4: 152-8. PMID: 15599665
- Ambroxol in the 21st century: pharmacological and clinical update. | Malerba, M. and Ragnoli, B. 2008. Expert Opin Drug Metab Toxicol. 4: 1119-29. PMID: 18680446
- Antiinflammatory properties of ambroxol. | Beeh, KM., et al. 2008. Eur J Med Res. 13: 557-62. PMID: 19073395
- Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole. | Li, X., et al. 2017. Front Cell Infect Microbiol. 7: 124. PMID: 28439502
- Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis. | Bouscary, A., et al. 2019. Front Pharmacol. 10: 883. PMID: 31447678
- The pharmacology of ambroxol--review and new results. | Disse, BG. 1987. Eur J Respir Dis Suppl. 153: 255-62. PMID: 3322865
- Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells. | Md, S., et al. 2021. Gels. 7: PMID: 34940303
- Facile approaches for determination of Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride using Eosin Y. | El-Sayed, A., et al. 2022. Ann Pharm Fr. 80: 687-696. PMID: 34968477
- Ambroxol increases the choline but not fatty acid incorporation into lung phospholipids in experimental lung disorders. | Wilke, A., et al. 1987. Respiration. 52: 129-36. PMID: 3671891
- Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice. | Nowak, D., et al. 1995. Free Radic Biol Med. 19: 659-63. PMID: 8529925
Inhibitor of:
HAPLN3, HAPLN4, O-Ac GD3, and Sodium Channel Protein.Activator of:
GalNAc-T1, KV4.1, LYAG, and SP-B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ambroxol hydrochloride, 1 g | sc-200816 | 1 g | $55.00 |