Molecular structure of 5-(N-Methyl-N-isobutyl)-Amiloride, CAS Number: 96861-65-3
5-(N-Methyl-N-isobutyl)-Amiloride (CAS 96861-65-3)
Application:
5-(N-Methyl-N-isobutyl)-Amiloride is an NHE inhibitor
CAS Number:
96861-65-3
Purity:
≥97%
Molecular Weight:
299.8
Molecular Formula:
C11H18ClN7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
5-(N-Methyl-N-isobutyl)-Amiloride is a compound that functions as a potent and selective inhibitor of the epithelial sodium channel (ENaC). It acts by binding to the extracellular domain of the channel, blocking the passage of sodium ions through the channel pore. This inhibition of ENaC activity leads to a reduction in sodium reabsorption in the kidney, which can be useful in studies investigating the regulation of blood pressure, fluid balance, and electrolyte homeostasis. 5-(N-Methyl-N-isobutyl)-Amiloride has been utilized in various physiological processes, such as the control of airway surface liquid volume in the lungs and the regulation of salt taste perception in the tongue.
5-(N-Methyl-N-isobutyl)-Amiloride (CAS 96861-65-3) References
- Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats. | Lauro, KL., et al. 1999. Brain Res. 831: 64-71. PMID: 10411984
- Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart. | Xiao, XH. and Allen, DG. 1999. Circ Res. 85: 723-30. PMID: 10521246
- Specific interaction of 5-(N-methyl-N-isobutyl)amiloride with the organic cation-proton antiporter in human placental brush-border membrane vesicles. Transport and binding. | Prasad, PD., et al. 1992. J Biol Chem. 267: 23632-9. PMID: 1331095
- Effects of amiloride on distal renal tubule sodium and calcium absorption: dependence on luminal pH. | Mori, Y., et al. 1992. Pharmacol Toxicol. 70: 201-4. PMID: 1579546
- N-methyl-isobutyl-amiloride ameliorates brain injury when commenced before hypoxia ischemia in neonatal mice. | Kendall, GS., et al. 2006. Pediatr Res. 59: 227-31. PMID: 16439583
- Photolabeling of tonoplast from sugar beet cell suspensions by [h]5-(N-methyl-N-isobutyl)-amiloride, an inhibitor of the vacuolar na/h antiport. | Barkla, BJ., et al. 1990. Plant Physiol. 93: 924-30. PMID: 16667602
- Tonoplast ion channels from sugar beet cell suspensions : inhibition by amiloride and its analogs. | Pantoja, O., et al. 1990. Plant Physiol. 94: 1788-94. PMID: 16667917
- Mechanisms of cardiodepression by an Na+-H+ exchange inhibitor methyl-N-isobutyl amiloride (MIA) on the heart: lack of beneficial effects in ischemia-reperfusion injury. | Saini, HK., et al. 2007. Can J Physiol Pharmacol. 85: 67-78. PMID: 17487246
- Estimation of carrier density and turnover rate of the Na+/H+ exchanger in human platelets using 5-(N-methyl-N-[3H]isobutyl)- amiloride. | Rosskopf, D., et al. 1991. Biochem Biophys Res Commun. 176: 639-44. PMID: 1850998
- Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters. | Talor, Z., et al. 1989. Life Sci. 45: 517-23. PMID: 2549314
- Interactions of chloride and amiloride with the renal Na+/H/ antiporter. | Warnock, DG., et al. 1988. J Biol Chem. 263: 7216-21. PMID: 2835368
- Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. | Maidorn, RP., et al. 1993. Br J Cancer. 67: 297-303. PMID: 8381657
- Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC. | Novikova IYu, ., et al. 1993. Biochim Biophys Acta. 1178: 267-72. PMID: 8395891
Inhibitor of:
NHE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-(N-Methyl-N-isobutyl)-Amiloride, 5 mg | sc-202929 | 5 mg | $82.00 | |||
5-(N-Methyl-N-isobutyl)-Amiloride, 25 mg | sc-202929A | 25 mg | $189.00 |