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Flecainide acetate (CAS 54143-56-5)

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Alternate Names:
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Application:
Flecainide acetate is a cadiac Na+ channel blocker
CAS Number:
54143-56-5
Purity:
≥97%
Molecular Weight:
474.39
Molecular Formula:
C17H20F6N2O3•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Flecainide acetate is a class Ic antiarrhythmic agent that functions by inhibiting the fast inward sodium current in cardiac tissues. This inhibition results in a decrease in the rate of rise of the action potential, leading to a reduction in the conduction velocity in the atria, ventricles, and His-Purkinje system. At the cellular level, flecainide acetate binds to and blocks the open sodium channels during depolarization, thereby prolonging the refractory period and reducing excitability. Its precise blocking capability makes it particularly useful in studies focused on understanding the mechanisms of arrhythmogenesis and the electrophysiological properties of the heart under various experimental conditions. Researchers value flecainide acetate for its high efficacy and specificity, which enable detailed investigations into the ionic currents and their role in cardiac rhythm abnormalities.


Flecainide acetate (CAS 54143-56-5) References

  1. Safe and efficacious dosage of flecainide acetate for treating equine atrial fibrillation.  |  Ohmura, H., et al. 2000. J Vet Med Sci. 62: 711-5. PMID: 10945288
  2. Flecainide acetate for treatment of tachyarrhythmias in children: review of world literature on efficacy, safety, and dosing.  |  Perry, JC. and Garson, A. 1992. Am Heart J. 124: 1614-21. PMID: 1462922
  3. Stability of flecainide acetate in an extemporaneously compounded oral suspension.  |  Wiest, DB., et al. 1992. Am J Hosp Pharm. 49: 1467-70. PMID: 1529992
  4. Flecainide acetate acetic acid solvates.  |  Veldre, K., et al. 2011. J Pharm Sci. 100: 604-11. PMID: 21249720
  5. Flecainide acetate for resistant arrhythmias in the young: efficacy and pharmacokinetics.  |  Perry, JC., et al. 1989. J Am Coll Cardiol. 14: 185-91; discussion 192-3. PMID: 2500470
  6. Flecainide: Current status and perspectives in arrhythmia management.  |  Andrikopoulos, GK., et al. 2015. World J Cardiol. 7: 76-85. PMID: 25717355
  7. Intravenous flecainide acetate for the clinical management of paroxysmal tachycardias.  |  Nathan, AW., et al. 1987. Clin Cardiol. 10: 317-22. PMID: 3109795
  8. Encainide hydrochloride and flecainide acetate: two class 1c antiarrhythmic agents.  |  Chase, SL. and Sloskey, GE. 1987. Clin Pharm. 6: 839-50. PMID: 3119276
  9. Clinical electrophysiologic effects of flecainide acetate.  |  Mehta, D., et al. 1988. Cardiovasc Drugs Ther. 1: 599-603. PMID: 3155304
  10. The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats.  |  Chung, SY., et al. 2018. Acute Crit Care. 33: 34-41. PMID: 31723857
  11. Critical Aspects in the Preparation of Extemporaneous Flecainide Acetate Oral Solution for Paediatrics.  |  Casiraghi, A., et al. 2021. Pharmaceutics. 13: PMID: 34834378
  12. Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm.  |  Crijns, HJGM., et al. 2022. Circ Arrhythm Electrophysiol. 15: e010204. PMID: 35196871
  13. Measurement of flecainide acetate in human plasma by an extraction spectrophotofluorometric method.  |  Chang, SF., et al. 1983. Arzneimittelforschung. 33: 251-3. PMID: 6682665
  14. Electrophysiologic effects of flecainide acetate in patients with sinus nodal dysfunction.  |  Vik-Mo, H., et al. 1982. Am J Cardiol. 50: 1090-4. PMID: 7137036
  15. Flecainide acetate: concentration-response relationships for antiarrhythmic and electrocardiographic effects.  |  Boriani, G., et al. 1993. Int J Clin Pharmacol Res. 13: 211-9. PMID: 8150547

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Flecainide acetate, 10 mg

sc-203581
10 mg
$60.00

Flecainide acetate, 50 mg

sc-203581A
50 mg
$209.00