SOD-1 Inhibitors
Superoxide dismutase 1 (SOD1) inhibitors represent a class of chemical compounds that interact with the SOD1 enzyme to reduce its activity. The SOD1 enzyme plays a key role in the body's defense against oxidative stress, by catalyzing the conversion of superoxide radicals into hydrogen peroxide and molecular oxygen. However, excessive activity or misfolding of this enzyme can lead to a variety of pathological conditions, hence the interest in chemical compounds that can modulate its activity. SOD1 inhibitors can be classified into two broad categories based on their mode of action: direct inhibitors and indirect inhibitors. Direct inhibitors interact with the SOD1 enzyme itself, often by binding to the active site or otherwise altering the enzyme's structure to decrease its functionality.
On the other hand, indirect inhibitors reduce the activity of SOD1 by altering the overall cellular environment or by modulating other pathways that influence the activity of SOD1. For example, antioxidants such as N-acetylcysteine can indirectly inhibit SOD1 by maintaining the redox balance and preventing oxidative damage, thereby reducing the need for SOD1 activity. Similarly, compounds that scavenge free radicals, modulate the Nrf2 pathway, or alter the cellular redox status can also serve as indirect SOD1 inhibitors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $27.00 $68.00 $116.00 $360.00 | 74 | |
Apocynin inhibits the assembly of NADPH oxidase, thereby reducing the production of superoxide anions. This indirectly lowers the activity of SOD1 as there are fewer superoxide radicals for the enzyme to act upon. | ||||||
Diethyldithiocarbamic acid sodium salt trihydrate | 20624-25-3 | sc-202576 sc-202576A | 5 g 25 g | $19.00 $59.00 | 2 | |
Sodium diethyldithiocarbamate trihydrate is a copper chelator, and it inhibits SOD1 by chelating the copper ion that's necessary for the enzymatic activity of SOD1. | ||||||
MCI-186 | 89-25-8 | sc-200806 sc-200806A | 5 g 100 g | $20.00 $32.00 | 10 | |
Edaravone is a free radical scavenger. It inhibits SOD1 indirectly by reducing the amount of superoxide radicals, thus reducing the substrate for SOD1. | ||||||
N-tert-Butyl-a-phenylnitrone | 3376-24-7 | sc-202722 sc-202722A | 500 mg 1 g | $52.00 $89.00 | ||
PBN is a spin trapping agent. It inhibits SOD1 indirectly by trapping free radicals, thus reducing the substrate for SOD1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that exhibits antioxidant properties. It inhibits SOD1 indirectly by scavenging free radicals, reducing oxidative stress, and modulating Nrf2 pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound, displays antioxidant properties. It indirectly inhibits SOD1 by scavenging free radicals, reducing oxidative stress, and modulating Nrf2 pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It indirectly inhibits SOD1 by scavenging free radicals, reducing oxidative stress, and modulating Nrf2 pathway. | ||||||
Diallyl trisulfide | 2050-87-5 | sc-205645 sc-205645A | 100 mg 500 mg | $160.00 $405.00 | 3 | |
DATS is a garlic-derived organosulfur compound. It indirectly inhibits SOD1 by modulating the cellular redox status and activating the Nrf2 pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with potent antioxidant properties. It indirectly inhibits SOD1 by scavenging free radicals, reducing oxidative stress, and modulating Nrf2 pathway. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic Acid is an organosulfur compound found in caprylic acid. It indirectly inhibits SOD1 by acting as an antioxidant, reducing oxidative stress, and modulating Nrf2 pathway. | ||||||