Superoxide Dismutase 1/SOD1 Antibody (G-11): sc-17767

SOD-1 Antibody (G-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects SOD-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SOD-1 (G-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Cu-Zn superoxide dismutase-1 (SOD-1) protein plays a crucial role in cellular defense against oxidative stress by catalyzing the conversion of superoxide radicals into hydrogen peroxide and molecular oxygen, thereby protecting cells from oxidative damage. This enzymatic activity is vital for maintaining cellular homeostasis, particularly in tissues with high metabolic rates, such as the brain and muscles. SOD-1 is predominantly located in the cytosol and functions as a homodimer, with SOD-1 activity being dependent on the binding of copper and zinc ions. Mutations in the SOD-1 gene have been linked to severe neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS), where the loss of SOD-1 scavenging function leads to increased oxidative stress and neuronal death. Understanding the function and importance of SOD-1 is essential for developing therapeutic strategies aimed at mitigating oxidative damage in various diseases.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 1/SOD1 Antibody (G-11) has 61 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 1/SOD1 Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 1/SOD1 Antibody (G-11) Specifications

Alternate Product Name: SOD1

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-154

Epitope Target: SOD-1

Epitope Species: human

Product Reactivity/Detection: SOD-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 61 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 1/SOD1 Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Superoxide Dismutase 1/SOD1 antibody is Superoxide Dismutase 1/SOD1 Antibody (B-1): sc-271014.