Superoxide Dismutase 1/SOD1 Antibody (B-1): sc-271014

SOD-1 Antibody (B-1) is a mouse monoclonal IgM antibody that detects SOD-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SOD-1 antibody (B-1) is available in a non-conjugated form, specifically designed for researchers seeking to study the role of Cu-Zn superoxide dismutase-1 (SOD-1) in various biological contexts. SOD-1 is a crucial cytosolic enzyme that acts as a scavenger of superoxide radicals, converting them into less harmful hydrogen peroxide and molecular oxygen, thereby protecting cells from oxidative stress. This enzymatic activity is vital for maintaining cellular health, particularly in tissues that are highly susceptible to oxidative damage, such as the nervous system. SOD-1 functions as a homodimer and requires the binding of copper and zinc ions for activity, which underscores the importance of metal ion homeostasis in cellular defense mechanisms. Notably, mutations in SOD-1 have been linked to severe neurodegenerative conditions, including familial amyotrophic lateral sclerosis (ALS), where the loss of zinc binding leads to diminished scavenging activity and increased neurotoxicity, ultimately resulting in motor neuron degeneration. Understanding SOD-1 and its interactions with other cellular components is essential for elucidating the mechanisms underlying these diseases and developing potential therapeutic strategies.

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Superoxide Dismutase 1/SOD1 Antibody (B-1) References:

1. Prevention of impairment of cerebral blood flow autoregulation during acute stage of subarachnoid hemorrhage by gene transfer of Cu/Zn SOD-1 to cerebral vessels.  |  Shin, HK., et al. 2003. J Cereb Blood Flow Metab. 23: 111-20. PMID: 12500096
2. Purification and Partial Characterization of a Genetically-Defined Superoxide Dismutase (SOD-1) Associated with Maize Chloroplasts.  |  Baum, JA., et al. 1983. Plant Physiol. 73: 31-5. PMID: 16663180
3. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.  |  Yen, K., et al. 2009. Mech Ageing Dev. 130: 173-8. PMID: 19059428
4. Differential motor neuron impairment and axonal regeneration in sporadic and familiar amyotrophic lateral sclerosis with SOD-1 mutations: lessons from neurophysiology.  |  Bocci, T., et al. 2011. Int J Mol Sci. 12: 9203-15. PMID: 22272128
5. A novel mutation of SOD-1 (Gly 108 Val) in familial amyotrophic lateral sclerosis.  |  Orrell, RW., et al. 1997. Eur J Neurol. 4: 48-51. PMID: 24283821
6. Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.  |  Levanon, D., et al. 1985. EMBO J. 4: 77-84. PMID: 3160582
7. cDNA and deduced amino acid sequence of murine Cu-Zn superoxide dismutase.  |  Bewley, GC. 1988. Nucleic Acids Res. 16: 2728. PMID: 3362683
8. A novel SOD mutant and ALS.  |  Orrell, R., et al. 1995. Nature. 374: 504-5. PMID: 7700376
9. ALS, SOD and peroxynitrite.  |  Beckman, JS., et al. 1993. Nature. 364: 584. PMID: 8350919
10. Mutations in all five exons of SOD-1 may cause ALS.  |  Shaw, CE., et al. 1998. Ann Neurol. 43: 390-4. PMID: 9506558
11. Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2.  |  Singh, RJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 6675-80. PMID: 9618471
12. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.  |  Bruijn, LI., et al. 1998. Science. 281: 1851-4. PMID: 9743498

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 1/SOD1 Antibody (B-1) has 65 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 1/SOD1 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 1/SOD1 Antibody (B-1) Specifications

Alternate Product Name: SOD1

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids: 130-146

Epitope Target: SOD-1

Epitope Species: human

Product Reactivity/Detection: SOD-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 65 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 1/SOD1 Antibody (B-1): P: Blocking Peptide