SNX22 Activators
SNX22 Activators are a class of chemical compounds that can enhance the functional activity of SNX22 through distinct pathways. Wortmannin and LY294002 act by inhibiting PI3K, a key player in endosome trafficking. By inhibiting PI3K, these compounds can indirectly enhance the activity of SNX22, a component of the retromer complex involved in the endosome-to-Golgi retrieval of proteins. U18666A is another SNX22 activator that disrupts cholesterol transport, leading to the accumulation of cholesterol in late endosomes and lysosomes, thereby indirectly enhancing the activity of SNX22. Dynasore and MiTMAB are dynamin inhibitors that prevent the scission of newly formed vesicles from the plasma membrane. By inhibiting dynamin, these compounds enhance the activity of SNX22, which is involved in protein sorting.
Genistein can also enhance the activity of SNX22 by affecting endocytosis. Chlorpromazine, a cationic amphiphilic drug, influences endocytosis and intracellular trafficking, thus enhancing the activity of SNX22. Bafilomycin A1 and Concanamycin A are specific inhibitors of V-ATPase that affect endosomal pH and protein sorting, thereby enhancing the activity of SNX22. Monensin disrupts endosomal protein trafficking by altering intracellular ionic concentrations. Nocodazole and Colchicine, by disrupting microtubule dynamics, can also enhance the activity of SNX22.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and selective inhibitor of phosphoinositide 3-kinases (PI3K), including the class III PI3K Vps34 involved in endosome trafficking. By inhibiting Vps34, Wortmannin can enhance the activity of SNX22, as it is a component of the retromer complex that sorts proteins from endosomes to the trans-Golgi network. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Similarly to Wortmannin, LY294002 is a broad-spectrum inhibitor of PI3K. By inhibiting PI3K, LY294002 can indirectly enhance the activity of SNX22, which is involved in the retromer-mediated endosome-to-Golgi retrieval of proteins. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A disrupts cholesterol transport and induces the accumulation of cholesterol in late endosomes and lysosomes. This can enhance the activity of SNX22, as SNX22 is involved in the retromer-mediated endosome-to-Golgi retrieval pathway. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a cell-permeable small molecule that inhibits dynamin, a GTPase involved in membrane fission during endocytosis. By inhibiting dynamin, Dynasore can enhance the activity of SNX22, which is a component of the retromer complex involved in endosomal protein sorting. | ||||||
Dynamin Inhibitor II | 1119-97-7 | sc-203931 sc-203931A sc-203931B sc-203931C | 5 g 250 g 500 g 1 kg | $47.00 $84.00 $124.00 $198.00 | ||
MiTMAB is a dynamin inhibitor that prevents the scission of newly formed vesicles from the plasma membrane. By inhibiting dynamin, MiTMAB can enhance the activity of SNX22, which plays a role in the endosome-to-Golgi retrieval of proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that affects various cellular processes, including endocytosis. By inhibiting tyrosine kinase, Genistein can enhance the activity of SNX22, which is involved in the sorting of endosomal proteins via the retromer complex. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is a cationic amphiphilic drug that causes the accumulation of phospholipids in cells, affecting endocytosis and intracellular trafficking. By influencing these processes, Chlorpromazine can enhance the activity of SNX22, which is a component of the retromer complex involved in endosome-to-Golgi retrieval. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase) that affects endosomal pH and protein trafficking. By inhibiting V-ATPase, Bafilomycin A1 can enhance the activity of SNX22, which is involved in the sorting of endosomal proteins. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A, like Bafilomycin A1, is a V-ATPase inhibitor that can influence endosomal pH and protein sorting. By inhibiting V-ATPase, Concanamycin A can enhance the activity of SNX22, a component of the retromer complex. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a polyether antibiotic that alters intracellular ionic concentrations and disrupts endosomal protein trafficking. By influencing these processes, Monensin can enhance the activity of SNX22, which is involved in the endosome-to-Golgi retrieval of proteins. | ||||||