Dynamin Inhibitor II is a cell-permeable cationic surfactant that reversibly inhibits Dynamin I GTPase activity (IC50 = 3.15 μM) by targeting the PH domain and interfering with phospholipid binding. Dynamin Inhibitor II has been shown to block Dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and Dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP. Dynamin Inhibitor II is an inhibitor of Dynamin II.
1. Quan, A., et al. 2007. Mol. Pharmacol. 72:1425. 2. Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14: 3275.
Soluble in water (10% (w/v)), ethanol, DMSO (10 mg/ml), and methanol.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Dynamin Inhibitor II was reported as a reversibleDynamin Inhibitor II was reported as a reversible inhibitor of Dynamin I GTPase activity by interfering with phospholipid binding, in many articles. -SCBT Publication Review
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