SNX14 Activators
Chemical activators of SNX14 operate through a variety of mechanisms to enhance its function in cellular processes such as endosomal sorting and protein trafficking. Phorbol 12-myristate 13-acetate (PMA) and 1,2-Dioctanoyl-sn-glycerol (DiC8), both being activators of protein kinase C (PKC), can lead to the phosphorylation of SNX14, which is a post-translational modification known to increase the activity of proteins. Similarly, Forskolin and 8-Bromo-cAMP, by elevating intracellular cAMP levels, activate protein kinase A (PKA), another kinase that can phosphorylate SNX14 and promote its role within the endosomal system. This is crucial as phosphorylation is a common regulatory mechanism that can alter the function and efficiency of proteins involved in trafficking pathways.
On the same note, ionophores like Ionomycin and A23187 (Calcimycin) increase the intracellular calcium concentration, which can activate various calcium-dependent kinases that are capable of phosphorylating SNX14, thus enhancing its activity related to membrane dynamics. Thapsigargin, by disrupting calcium storage, also leads to an increase in cytosolic calcium levels, further contributing to the activation of calcium-dependent kinases that phosphorylate SNX14. Additionally, the inhibition of protein phosphatases by Okadaic acid and Calyculin A prevents the dephosphorylation of SNX14, thereby maintaining its phosphorylated and active state. Anisomycin, through the activation of stress-activated protein kinases, and Bryostatin 1, as a direct PKC activator, also contribute to the phosphorylation and subsequent activation of SNX14. Lastly, Piceatannol, by inhibiting Syk kinase, can alter signaling pathways that indirectly lead to the functional activation of SNX14, ensuring that it plays its part in the complex cellular processes of protein sorting and trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which is known to regulate trafficking and sorting of proteins through the endosomal system, a process SNX14 is involved in. PKC activation can lead to SNX14 activation by enhancing its endosomal sorting function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as an ionophore that significantly increases intracellular calcium levels, which can activate calcium-dependent kinases. These kinases can then phosphorylate SNX14, thereby directly increasing its functional activity related to membrane dynamics. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin is another calcium ionophore that elevates intracellular calcium levels and can activate kinases that phosphorylate SNX14, thus enhancing its protein sorting and trafficking capabilities. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA in turn can phosphorylate SNX14, which is directly involved in the endosomal sorting process, thus promoting its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, maintaining proteins in a phosphorylated state. This sustained phosphorylation can enhance the activity of SNX14 by preserving its phosphorylation-dependent functional state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like okadaic acid, inhibits protein phosphatases leading to increased phosphorylation of proteins. This could enhance SNX14 activity by maintaining its phosphorylation state, crucial for its role in endosomal sorting mechanisms. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol (DAG) and acts as a PKC activator. By activating PKC, DiC8 can lead to the phosphorylation of SNX14, which may increase its activity in protein sorting processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium storage and increases cytosolic calcium, which activates calcium-dependent kinases. These kinases are potential activators of SNX14 by phosphorylating and thereby increasing its sorting and trafficking functions. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases, which could phosphorylate SNX14. This phosphorylation could enhance SNX14's function in the cellular sorting pathways it is involved with. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a PKC activator that can lead to the activation of SNX14 by promoting its phosphorylation and enhancing its role in endosomal sorting and trafficking processes within cells. | ||||||