SNX13 Activators
SNX13 activators pertain to a niche of chemical compounds that are designed to interact with and modulate the function of the protein Sorting Nexin 13 (SNX13). SNX13 is a part of the sorting nexin family, which plays a pivotal role in intracellular trafficking, endosomal sorting, and signaling processes. These proteins are characterized by the presence of a Phox-homology (PX) domain, which is responsible for their interaction with phosphoinositides, a class of lipids that are crucial for various cellular processes. SNX13, in particular, is distinguished by its unique structural and functional features that enable it to engage with specific cellular membranes and proteins.
Activators of SNX13 are typically small molecule compounds that can influence the activity of the SNX13 protein. The interaction of these activators with SNX13 can lead to alterations in its conformation, affecting its binding affinity to phosphoinositides or its interaction with other proteins in the cell. This, in turn, can modulate the protein's role in endosomal sorting and trafficking. The precise mechanism by which these activators exert their effect on SNX13 is an area of ongoing research, as it involves complex protein-lipid and protein-protein interactions within the dynamic environment of the cell. Understanding the molecular underpinnings of how SNX13 activators function is critical for elucidating their role in the intricate web of cellular signaling pathways. These compounds are of interest in the biochemical and molecular biology fields, where they are used to probe the functions of SNX13 and its impact on cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly raises the levels of cyclic adenosine monophosphate (cAMP) in cells, which activates protein kinase A (PKA). PKA activation can lead to the phosphorylation of SNX13, enhancing its role in endosomal sorting and signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate SNX13, potentially enhancing its sorting activity within the endosomal pathway. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate can activate sphingosine-1-phosphate receptors, which through G-protein signaling may lead to the activation of downstream kinases that phosphorylate and activate SNX13, thereby influencing its role in membrane trafficking. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent kinases such as calmodulin-dependent kinase (CaMK), potentially leading to the phosphorylation and activation of SNX13. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, potentially reducing competitive signaling pathways and indirectly enhancing the functional activity of SNX13 in endocytic trafficking. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA, possibly resulting in the phosphorylation and activation of SNX13, thus affecting its role in endosomal sorting. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which may lead to increased phosphorylation levels of proteins including SNX13, thereby potentially enhancing its activity in cellular trafficking processes. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that may enhance the phosphorylation of SNX13, promoting its role in the trafficking and sorting of proteins within the endosomal system. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go 6983 is a potent PKC inhibitor that, by selectively inhibiting specific PKC isoforms, could indirectly enhance SNX13's activity by reducing competitive substrate phosphorylation. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a PKC activator that may lead to phosphorylation and activation of SNX13, thus promoting its function in membrane trafficking and protein sorting. | ||||||