Snf5 Activators
Snf5 Activators are a class of chemical compounds that enhance the functional activity of Snf5 through distinct pathways. Rapamycin directly activates Snf5 by inhibiting the mTOR pathway, releasing Snf5 from its repressed state. Lithium chloride, SB216763, and CHIR99021 act indirectly by inhibiting GSK3β, a negative regulator of Snf5. The inhibition of GSK3β prevents the suppression of Snf5, resulting in its activation. Trichostatin A and Vorinostat indirectly activate Snf5 by inhibiting HDACs, leading to increased acetylation of histones at the Snf5 promoter region, thereby increasing its activity.
5-Aza-2'-deoxycytidine and RG108 indirectly activate Snf5 by inhibiting DNA methyltransferases, leading to decreased methylation at the Snf5 gene promoter, enhancing its functional activity. PD0325901 indirectly activates Snf5 by inhibiting the MEK/ERK pathway, leading to the derepression of Snf5. LY294002 enhances Snf5 activity by inhibiting the PI3K/AKT pathway, which leads to decreased negative regulation of Snf5. BIX-01294 activates Snf5 by inhibiting the G9a histone methyltransferase. Finally, Y-27632 enhances Snf5 activity by inhibiting ROCK, a negative regulator of Snf5, thereby enhancing Snf5 activation.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin directly activates Snf5 by inhibiting the mTOR pathway. The inhibited mTOR pathway releases Snf5 from its repressed state, leading to its activation and increased functional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride indirectly activates Snf5 by inhibiting GSK3β, a negative regulator of Snf5. The inhibition of GSK3β prevents it from suppressing Snf5, resulting in its activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A indirectly activates Snf5 by inhibiting HDACs. HDAC inhibition results in increased acetylation of histones at the Snf5 promoter region, thereby increasing its activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine indirectly activates Snf5 by inhibiting DNA methyltransferases. This leads to decreased methylation at the Snf5 gene promoter, enhancing its functional activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 indirectly enhances Snf5 activity by inhibiting GSK3β, thereby preventing suppression of Snf5 and resulting in its activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 indirectly enhances Snf5 activity by inhibiting the PI3K/AKT pathway, which leads to decreased negative regulation of Snf5, thereby enhancing its functional activity. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 indirectly activates Snf5 by inhibiting the G9a histone methyltransferase, which prevents methylation at the Snf5 gene promoter, enhancing Snf5 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat indirectly enhances Snf5 activity by inhibiting HDACs. This leads to increased acetylation of histones at the Snf5 promoter, thereby increasing its activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 indirectly activates Snf5 by inhibiting GSK3β, which prevents its suppressive effect on Snf5, resulting in Snf5 activation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 indirectly enhances Snf5 activity by inhibiting DNA methyltransferases, leading to decreased methylation at the Snf5 gene promoter, thereby enhancing its functional activity. | ||||||