SMYD4 Activators
S-Adenosyl methionine (SAM), the principal methyl donor for methylation reactions. By maintaining a sufficient SAM pool, compounds such as folic acid, methylcobalamin, betaine, and choline ensure that SMYD4 has the necessary substrates for its enzymatic action. These compounds participate in the one-carbon metabolism and methylation cycles, indirectly bolstering SMYD4's methyltransferase function.
The chromatin state is another determinant of SMYD4 activity. Chemicals like Suberoylanilide Hydroxamic Acid, a histone deacetylase inhibitor, and 5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, promote a more relaxed chromatin configuration. This alteration in chromatin structure can potentially enhance the access of SMYD4 to its histone targets, thus facilitating the methylation process. Additionally, nicotinamide, resveratrol, genistein, curcumin, and epigallocatechin gallate, interact with cellular signaling pathways and can modulate the activity of various proteins involved in epigenetic regulation. These interactions, while not directly influencing SMYD4, can lead to changes in the cellular environment that support the protein's role in chromatin modification.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as a methyl donor for various methyltransferases, and it can be necessary for the methyltransferase activity of SMYD4. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As an inhibitor of DNA methyltransferases, this compound could lead to changes in chromatin structure that might favor SMYD4-mediated methylation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that can result in a more relaxed chromatin state, potentially enhancing SMYD4 access to histone substrates. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $306.00 | ||
A cofactor for methionine synthase in the SAM cycle, it is essential for maintaining SAM levels, which could influence SMYD4 activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Participates in the one-carbon metabolism pathway that generates SAM, indirectly supporting SMYD4's methyltransferase function. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Contributes to the methylation cycle as a methyl donor and might support SAM levels, influencing SMYD4 activity. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Involved in the production of betaine, which in turn can support the methylation cycle and SAM levels relevant to SMYD4 function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 that can influence sirtuin activity and epigenetic regulation, potentially affecting SMYD4-related pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that can modulate epigenetic enzymes and signaling pathways, possibly affecting SMYD4 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that can act on various signaling pathways and has been shown to influence histone methylation, possibly affecting SMYD4. | ||||||