SMYD4 Antibody (Ac-10): sc-517360
- SMYD4 Antibody (Ac-10) is a mouse monoclonal IgG1 SMYD4 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to SMYD4 of human origin
- recommended for detection of SMYD4 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SMYD4 Antibody (Ac-10). This work is in progress.
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SMYD4 Antibody (Ac-10) is a mouse monoclonal IgG1 antibody that detects SMYD4 protein of human origin by western blotting (WB). Anti-SMYD4 antibody (Ac-10) is available as a non-conjugated format. The SMYD (SET and MYND domain-containing) family of proteins, which includes SMYD1, SMYD2, SMYD3, and SMYD4, plays a crucial role in transcriptional regulation and interacts with the HDAC family of histone deacetylases, thereby influencing gene expression and cellular processes. SMYD4, also referred to as ZMYND21, is an 804 amino acid protein characterized by one SET domain and one MYND-type zinc finger, which are essential for mediating protein-protein interactions and transcriptional regulation. The SET domain is particularly important in histone methylation, a key post-translational modification that can alter chromatin structure and accessibility, ultimately affecting gene expression. SMYD4 dysregulation has been implicated in various diseases, including cancer, making SMYD4 a significant target for therapeutic intervention.
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SMYD4 Antibody (Ac-10) References:
- Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. | Gottlieb, PD., et al. 2002. Nat Genet. 31: 25-32. PMID: 11923873
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | Brandenberger, R., et al. 2004. Nat Biotechnol. 22: 707-16. PMID: 15146197
- SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. | Hamamoto, R., et al. 2004. Nat Cell Biol. 6: 731-40. PMID: 15235609
- Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. | Shao, GB., et al. 2014. In Vitro Cell Dev Biol Anim. 50: 603-13. PMID: 24619213
- SET domain proteins modulate chromatin domains in eu- and heterochromatin. | Jenuwein, T., et al. 1998. Cell Mol Life Sci. 54: 80-93. PMID: 9487389
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMYD4 Antibody (Ac-10) | sc-517360 | 100 µg/ml | $322.00 |