Smt3 Activators
Chemical classes known as Smt3 activators are not characterized as a group due to the indirect nature of their action. Rather, individual chemicals can influence pathways that indirectly enhance the SUMOylation process in which Smt3 is a key player. The chemicals listed above either inhibit enzymes that affect histone acetylation states, thus influencing gene expression and potentially SUMOylation, or they modulate cellular stress responses which are known to upregulate the SUMOylation process to protect cellular proteins under stress conditions.
The influence on Smt3 activity by these chemicals occurs through a diverse array of mechanisms. Some compounds may inhibit the proteasome, leading to the accumulation of proteins that require SUMOylation. Others may activate transcription factors, such as p53, or induce stress responses, both of which can lead to increased expression of components of the SUMOylation machinery, thereby indirectly promoting Smt3's role in SUMO conjugation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TW-37 | 877877-35-5 | sc-361387 sc-361387A | 10 mg 50 mg | $200.00 $860.00 | 2 | |
Tenovin-6 is a small molecule activator of p53 that leads to increased transcription of genes under p53 control, some of which can be involved in the SUMOylation pathway, possibly affecting the activity of SMT3. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is a NF-kB inhibitor that could influence the expression of genes involved in the SUMOylation pathway, thus affecting SMT3 activity indirectly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of sumoylated proteins, thus potentially increasing the demand for SMT3 activity for protein SUMOylation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is known to inhibit the proteasome and also induce heat shock responses. Heat shock proteins can modulate SUMO conjugating enzymes and thus could influence SMT3 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, can lead to DNA damage response activation, which is known to involve SUMOylation processes and could therefore increase the activity of SMT3. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol is an inhibitor of SIRT1 deacetylase. Since SIRT1 can remove acetyl groups from proteins and alter their SUMOylation status, sirtinol could indirectly enhance SMT3-mediated SUMOylation. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite induces oxidative stress and heat shock protein responses, both of which can modulate the SUMOylation pathway, potentially affecting SMT3 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has multiple cellular targets and has been shown to induce the expression of several genes, including those involved in the SUMOylation process, thus potentially enhancing SMT3 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates a wide array of molecular targets and could influence gene expression related to SUMOylation, thereby affecting the functional activity of SMT3. | ||||||