Smad7 Inhibitors
Smad7 is an integral component of the transforming growth factor-beta (TGF-β) signaling pathway, a pathway that holds significant importance in regulating a wide array of cellular processes including cell growth, differentiation, apoptosis, and homeostasis. The TGF-β signaling pathway involves several Smad proteins, which function as intracellular mediators. Among these, Smad7 is unique because, unlike other Smad proteins that propagate the TGF-β signal, Smad7 acts as an inhibitory Smad. Specifically, it negatively regulates TGF-β signaling by interfering with the activation of other Smad proteins and by promoting the degradation of TGF-β receptors.
As such, Smad7 plays a crucial role in ensuring that the TGF-β signaling is appropriately modulated, preventing excessive or prolonged activation of the pathway. Smad7 inhibitors are molecules designed to counteract the inhibitory function of Smad7 on the TGF-β pathway. By inhibiting Smad7, these compounds can enhance or restore the TGF-β signaling, particularly in situations where Smad7 might be overexpressed or hyperactive, leading to reduced TGF-β pathway activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate TGF-β signaling. It may reduce Smad7 expression, thereby promoting TGF-β signaling in certain contexts. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of TGF-β type I receptor ALK5 kinase, it can affect Smad7 expression indirectly by altering pathway dynamics. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
As a TGF-β receptor I kinase inhibitor, galunisertib might affect Smad7 expression indirectly through modulation of the TGF-β pathway. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A TGF-β type I receptor kinase inhibitor that may influence Smad7 levels by altering TGF-β signaling dynamics. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
Inhibits TGF-β type I receptor kinase and may down-regulate Smad7 as part of its impact on the TGF-β pathway. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
An inhibitor of TGF-β receptor I and II, its modulation of the pathway might impact Smad7 expression. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
By targeting the TGF-β type I receptor ALK5, RepSox might indirectly affect Smad7 expression in cells. | ||||||
TGF-β RI Kinase Inhibitor VIII | 356559-20-1 | sc-203295 | 2 mg | $100.00 | 2 | |
As it inhibits TGF-β type I receptor ALK5 kinase, it can alter Smad7 dynamics indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that might influence TGF-β signaling, potentially leading to changes in Smad7 expression. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
While its exact mechanism is unknown, it has shown anti-fibrotic effects which might involve down-regulation of Smad7. | ||||||