Smad7 Activators
Smad7 activators belong to a distinct class of chemical agents that interact with the cellular signaling pathways, specifically targeting the Smad family of proteins. Smad7 is an intracellular protein that plays a critical role in the Transforming Growth Factor-beta (TGF-β) signaling pathway, which is a highly conserved pathway across various species and is pivotal in regulating cell proliferation, differentiation, and apoptosis. Unlike other Smad proteins that propagate TGF-β signals, Smad7 functions as an inhibitory Smad (I-Smad) and negatively regulates this pathway. When activated, Smad7 binds to the TGF-β receptors, preventing the phosphorylation and subsequent activation of receptor-regulated Smads (R-Smads), such as Smad2 and Smad3. This binding not only blocks further signal transduction but also targets the TGF-β receptors for degradation, thus exerting a negative feedback loop on the pathway.
Chemical agents that serve as Smad7 activators modulate this inhibition mechanism, effectively increasing the levels or activity of Smad7 within the cell. The upregulation of Smad7 by these activators can lead to the attenuation of TGF-β signaling. The complexity of the TGF-β/Smad signaling network is vast, with numerous points of potential interaction, and Smad7 activators can be designed to affect this pathway at different stages. These chemicals can either increase the expression of the Smad7 gene or enhance the stability of the Smad7 protein, thereby amplifying its inhibitory effects.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin directly enhances Smad7 function by suppressing the TGF-β signaling pathway. Acting as a TGF-β receptor inhibitor, curcumin disrupts Smad2/3 phosphorylation, leading to increased Smad7 expression. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2, a Src inhibitor, indirectly enhances Smad7 function by modulating Src-mediated signaling pathways. By inhibiting Src activation, PP2 prevents the phosphorylation of Smad7, leading to increased Smad7 stability. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid directly enhances Smad7 function by inhibiting the TGF-β signaling pathway. Acting as a TGF-β receptor antagonist, valproic acid disrupts Smad2/3 phosphorylation, leading to increased Smad7 expression. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
A83-01, a TGFBR1/ALK5 inhibitor, directly enhances Smad7 function by blocking the TGF-β signaling pathway. By inhibiting TGFBR1/ALK5, A83-01 prevents Smad2/3 phosphorylation, leading to increased Smad7 expression. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Vismodegib indirectly enhances Smad7 function by inhibiting the Hedgehog signaling pathway. By blocking Smoothened (SMO), Vismodegib attenuates Gli-mediated transcription of Smad7, preventing its degradation. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $111.00 | 2 | |
Norcantharidin directly enhances Smad7 activity by inhibiting the TGF-β signaling pathway. Acting as a TGF-β receptor antagonist, norcantharidin disrupts Smad2/3 phosphorylation, leading to increased Smad7 expression. | ||||||