SLN Activators
SLN activators refer to a class of chemicals that modulate the activity of the protein sarcolipin (SLN), which is involved in muscle physiology. Sarcolipin is a small, regulatory peptide that is known to influence the activity of the sarcoplasmic reticulum Ca²⁺-ATPase (SERCA) pump, which plays a critical role in muscle contraction and relaxation by regulating calcium ion homeostasis within muscle cells. SLN binds to SERCA and acts as an inhibitor under normal physiological conditions; however, SLN activators function by either directly interacting with SLN to reduce its inhibitory effect on SERCA or by modulating the signaling pathways that control the expression and function of SLN.
The mechanisms by which SLN activators exert their effects can vary. Some may bind directly to SLN, altering its conformation so that its interaction with SERCA is less effective, thereby enhancing calcium uptake into the sarcoplasmic reticulum and facilitating muscle relaxation. Other activators might work indirectly by influencing the phosphorylation state of SLN through kinase pathways, which can modulate SLN's ability to inhibit SERCA. Additionally, activators could act at the gene expression level, increasing the synthesis of SLN so that it is more available for post-translational modifications that attenuate its inhibitory action on SERCA
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels. The elevation in cAMP levels activates protein kinase A (PKA), a known participant in the SLN regulation pathway. PKA phosphorylation of SLN enhances its activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin stimulates the PI3K/AKT pathway. Activation of this pathway leads to phosphorylation and activation of mTOR, which has been implicated in the modulation of SLN. This can lead to increased activity of SLN. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Despite its inhibitory action, in certain contexts, the inhibition of mTOR can induce a feedback activation of the PI3K/AKT pathway, which can then activate SLN. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin stimulates the AMPK pathway. Activation of this pathway can lead to the inhibition of mTOR, which may result in a feedback activation of the PI3K/AKT pathway, activating SLN. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin triggers the NRF2 pathway, which can lead to the upregulation of antioxidant enzymes, including SLN. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol stimulates the SIRT1 pathway, which can activate PGC-1α. PGC-1α upregulates the expression of SLN, leading to its activation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin triggers the TRPV1 pathway. Activation of this pathway can lead to increases in intracellular calcium, which can activate calmodulin. Calmodulin activation can modulate SLN activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine stimulates the AMPK pathway, which leads to a decrease in mTOR activity. This can result in a feedback activation of the PI3K/AKT pathway, which can activate SLN. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin triggers the PKA pathway, which can lead to the phosphorylation and activation of SLN. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG stimulates the AMPK pathway, which can lead to a decrease in mTOR activity. This can result in a feedback activation of the PI3K/AKT pathway, which can activate SLN. | ||||||