SLC22A11 Activators
SLC22A11 Activators are chemical compounds that indirectly increase the functional activity of the SLC22A11 protein through a variety of cellular signaling mechanisms. Forskolin, Aminophylline, and Caffeine enhance SLC22A11 activity by increasing intracellular cAMP levels, which activates PKA, a kinase known to phosphorylate substrates that regulate transporter activity. Sulforaphane's activation of the Nrf2 pathway suggests an upregulation of antioxidant response elements, potentially increasing SLC22A11's role in detoxification processes. Moreover, Zinc Pyrithione may adjust intracellular ion gradients, thereby indirectly promoting SLC22A11 transporter function, and Curcumin's modulation of NF-κB signaling is thought to transcriptionally upregulate SLC22A11, contributing to its enhanced activity.
Meanwhile, Resveratrol's activation of SIRT1 signaling and Nicotinamide Riboside's enhancement of NAD+ biosynthesis are likely to lead to the transcriptional activation and increased function of SLC22A11 by improving cellular metabolic balance. Piperine could enhance SLC22A11 activity by modulating the bioavailability of substrates and influencing transporter expression, while Quercetin's kinase inhibition may stabilize the active configuration of SLC22A11. Lastly, Silymarin and Epigallocatechin Gallate, by affecting cellular transporters and modulating critical signaling pathways such as NF-κB, are poised to contribute to the increased activity of SLC22A11.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, which increases intracellular cAMP levels. This elevation of cAMP leads to PKA activation, enhancing SLC22A11 by increasing its transporter activity. | ||||||
Aminophylline | 317-34-0 | sc-252368 | 25 g | $36.00 | ||
Aminophylline inhibits phosphodiesterase to prevent cAMP breakdown, indirectly leading to enhanced SLC22A11 activity through increased PKA signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which can lead to transcriptional activation of antioxidant response elements, enhancing SLC22A11 activity through improved detoxification processes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione modulates ionic channels and transporters, which can indirectly increase SLC22A11 transporter activity by modifying intracellular ion gradients. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences NF-κB signaling, which can lead to the transcriptional upregulation of SLC22A11 and enhance its transporter function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which may indirectly upregulate SLC22A11 by deacetylating and activating transcription factors that increase SLC22A11 expression. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine interacts with enzymes and transporters, which could enhance SLC22A11 activity by increasing substrate bioavailability or transporter expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits kinase activity, which can stabilize SLC22A11 in its active form and enhance its function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine's role as a phosphodiesterase inhibitor indirectly increases cAMP levels, potentially enhancing SLC22A11 transporter activity via PKA-mediated pathways. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide Riboside boosts NAD+ biosynthesis, which can lead to increased SLC22A11 activity by promoting better cellular metabolism and homeostasis. | ||||||