SLC10A4 Activators
SLC10A4, a member of the solute carrier family 10, plays a pivotal role in the cellular uptake of various compounds, including bile acids, steroids, and thyroid hormones. As a transmembrane transporter, SLC10A4 is essential for maintaining cellular homeostasis and regulating metabolic processes through the transport of substrates across the cell membrane. Functionally, SLC10A4 is involved in bile acid recycling, steroid hormone signaling, and thyroid hormone metabolism, highlighting its significance in diverse physiological functions.
Activation of SLC10A4 is intricately regulated by various cellular signaling pathways and molecular mechanisms. One prominent mode of activation involves the modulation of gene expression through epigenetic modifications, such as histone acetylation and deacetylation. Compounds like sodium butyrate, retinoic acid, and curcumin activate SLC10A4 by promoting histone acetylation, leading to enhanced transcription of the SLC10A4 gene and increased transporter expression and activity. Additionally, certain agents, such as forskolin and sulforaphane, activate SLC10A4 by stimulating specific signaling pathways, such as the cAMP-PKA pathway and the Nrf2-mediated antioxidant response, respectively, resulting in the upregulation of transporter function. Overall, the activation of SLC10A4 is a tightly regulated process involving multiple cellular pathways and molecular mechanisms, ensuring proper substrate transport and cellular function.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates SLC10A4 by stimulating adenylate cyclase, leading to increased intracellular cAMP levels and subsequent activation of SLC10A4 transporter function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate activates SLC10A4 by promoting histone acetylation, which enhances transcription of SLC10A4 gene, resulting in increased expression and activity of the transporter. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates SLC10A4 by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to enhanced transcription of SLC10A4 gene and increased transporter expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates SLC10A4 by modulating AMPK signaling pathway, which promotes SLC10A4 translocation to the cell membrane and enhances transporter activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates SLC10A4 by inhibiting NF-κB signaling pathway, leading to decreased inflammatory response and subsequent upregulation of SLC10A4 gene expression and transporter activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) activates SLC10A4 by inhibiting HDAC activity, resulting in histone acetylation and enhanced transcription of SLC10A4 gene, leading to increased transporter expression and activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates SLC10A4 by inducing Nrf2-mediated antioxidant response, which upregulates SLC10A4 gene expression and enhances transporter activity. | ||||||
Sodium propionate | 137-40-6 | sc-251043B sc-251043 sc-251043A sc-251043C sc-251043D sc-251043E | 100 g 250 g 1 kg 2.5 kg 5 kg 10 kg | $26.00 $47.00 $67.00 $109.00 $193.00 $349.00 | ||
Sodium propionate activates SLC10A4 by promoting histone acetylation, leading to increased transcription of SLC10A4 gene and subsequent upregulation of transporter expression and activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates SLC10A4 by inhibiting NF-κB signaling pathway, resulting in decreased inflammation and enhanced transcription of SLC10A4 gene, leading to increased transporter activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide activates SLC10A4 by stimulating sirtuin deacetylase activity, leading to histone deacetylation and enhanced transcription of SLC10A4 gene, resulting in increased transporter expression and activity. | ||||||