Date published: 2025-10-13

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Sodium propionate (CAS 137-40-6)

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Alternate Names:
Propionic acid sodium salt
CAS Number:
137-40-6
Molecular Weight:
96.06
Molecular Formula:
C3H5O2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium propionate, also referred to as sodium propanoate, is a white crystalline substance utilized across various fields such as food preservation, and laboratory investigations. It serves as a salt derived from propionic acid, a natural product produced by certain bacteria, fungi, and animals. Additionally, sodium propionate is instrumental in the production of propionic acid, which holds significant importance in various biochemical processes.


Sodium propionate (CAS 137-40-6) References

  1. Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress.  |  Tong, LC., et al. 2016. Front Pharmacol. 7: 253. PMID: 27574508
  2. SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD.  |  Deng, M., et al. 2020. J Endocrinol. 245: 425-437. PMID: 32302970
  3. The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice.  |  Hu, X., et al. 2020. ISME J. 14: 1897-1910. PMID: 32341472
  4. Sodium Propionate Attenuates the Lipopolysaccharide-Induced Epithelial-Mesenchymal Transition via the PI3K/Akt/mTOR Signaling Pathway.  |  Chen, D., et al. 2020. J Agric Food Chem. 68: 6554-6563. PMID: 32452677
  5. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling.  |  Park, HS., et al. 2021. Acta Pharmacol Sin. 42: 1311-1323. PMID: 32973326
  6. Sodium propionate protect the blood-milk barrier integrity, relieve lipopolysaccharide-induced inflammatory injury and cells apoptosis.  |  Ali, I., et al. 2021. Life Sci. 270: 119138. PMID: 33524422
  7. Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.  |  Chen, D., et al. 2021. J Inflamm Res. 14: 803-816. PMID: 33732006
  8. Sodium acetate, propionate, and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes.  |  Jiao, A., et al. 2021. Nutrition. 87-88: 111198. PMID: 33761444
  9. Effect of a diet enriched with sodium propionate on growth performance, antioxidant property, innate-adaptive immune response, and growth-related genes expression in critically endangered beluga sturgeon (Huso huso).  |  Ahmadifar, E., et al. 2022. Fish Shellfish Immunol. 125: 101-108. PMID: 35472403
  10. Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p.  |  Ma, S., et al. 2022. Autoimmunity. 55: 378-387. PMID: 35549788
  11. Exposure of zebrafish embryos to sodium propionate disrupts circadian behavior and glucose metabolism-related development.  |  Xu, YX., et al. 2022. Ecotoxicol Environ Saf. 241: 113791. PMID: 35753272
  12. The food preservative sodium propionate induces hyperglycaemic state and neurological disorder in zebrafish.  |  Xu, YX., et al. 2022. Neurotoxicol Teratol. 93: 107123. PMID: 36150581
  13. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease.  |  Lang, W., et al. 2022. Neurosci Lett. 791: 136887. PMID: 36174844
  14. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling.  |  Filippone, A., et al. 2022. Cancers (Basel). 15: PMID: 36612214
  15. Sodium Propionate or Sodium Butyrate Promotes Fatty Acid Oxidation in HepG2 Cells Under Oxidative Stress.  |  Cook, KJ., et al. 2023. J Med Food. 26: 74-79. PMID: 36637439

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium propionate, 100 g

sc-251043B
100 g
$25.00

Sodium propionate, 250 g

sc-251043
250 g
$46.00

Sodium propionate, 1 kg

sc-251043A
1 kg
$66.00

Sodium propionate, 2.5 kg

sc-251043C
2.5 kg
$107.00

Sodium propionate, 5 kg

sc-251043D
5 kg
$189.00

Sodium propionate, 10 kg

sc-251043E
10 kg
$342.00