Skint3 Inhibitors
Chemical inhibitors of Selection and Upkeep of Intraepithelial T cells 3 (SKINT3) offer various mechanisms to inhibit the functional aspects of this protein. Staurosporine is a potent protein kinase C inhibitor that obstructs the activation of protein kinase C, a crucial player in T cell receptor signaling. This inhibition disrupts the downstream processes that would normally lead to the activation of SKINT3. Wortmannin and LY294002, both specific phosphoinositide 3-kinase (PI3K) inhibitors, impede the PI3K-dependent signaling pathways. Since PI3K is integral to T cell development and function, its inhibition can lead to a decrease in the activation signals necessary for SKINT3 to function. Furthermore, PP2, an Src family kinase inhibitor, targets Lck and Fyn, key components in T cell receptor signaling, again leading to a reduction in the necessary activation signals for SKINT3.
Continuing with the theme of targeting kinase signaling, U0126 and PD98059 are selective inhibitors of MEK1/2, and by impeding the MAPK/ERK pathway, they reduce the activation signals critical for SKINT3's role in T cell activities. SP600125, which inhibits c-Jun N-terminal kinase, and SB203580, a p38 MAPK inhibitor, both disrupt crucial signaling pathways necessary for T cell differentiation and function, thereby inhibiting the functional role of SKINT3. Rapamycin, an mTOR inhibitor, and Cyclosporin A, a calcineurin inhibitor, target more distal elements of the T cell activation cascade, which are essential for the activation of SKINT3. Chelerythrine and Go6983, both functioning as protein kinase C inhibitors, prevent the activation of vital signaling pathways that SKINT3 requires for its functional role within T cells. By targeting these specific pathways and enzymes, these chemicals collectively ensure the inhibition of SKINT3 by disrupting the necessary signaling events that underpin its function in the maintenance and development of intraepithelial T cells.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent protein kinase C inhibitor that can inhibit the signaling pathways involving protein kinase C, which upon inhibition could lead to the downstream inhibition of selection and upkeep of intraepithelial T cells 3 (SKINT3) by preventing its activation through those pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphoinositide 3-kinase inhibitor that can inhibit PI3K-dependent signaling pathways, which are involved in T cell development and function, thereby potentially leading to the functional inhibition of SKINT3 due to impaired T cell receptor signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases, which by inhibiting PI3K, could lead to the inhibition of downstream signaling necessary for the function of SKINT3. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
An Src family kinase inhibitor that can inhibit Lck and Fyn, leading to the inhibition of T cell receptor signaling pathways that are essential for the function of SKINT3. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway; by inhibiting this pathway, U0126 can impede the activation signals that are required for SKINT3 to function in T cell activities. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A specific inhibitor of MEK, which prevents the activation of MAPK/ERK pathway; the inhibition of this pathway can lead to the downregulation of signals essential for SKINT3's role in T cell selection and upkeep. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which plays a role in T cell activation and differentiation; inhibiting JNK can lead to functional inhibition of SKINT3 by disrupting necessary T cell signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can inhibit T cell activation and proliferation; by doing so, rapamycin can indirectly inhibit SKINT3's function associated with intraepithelial T cell development and maintenance. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An inhibitor of calcineurin, which prevents the activation of NFAT, a key transcription factor in T cells; by inhibiting this pathway, Cyclosporin A can indirectly inhibit the functional activation of SKINT3. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor which can inhibit the signaling required for T cell differentiation and function, potentially leading to the functional inhibition of SKINT3. | ||||||