Sialyltransferase 7F Inhibitors
Sialyltransferase 7F inhibitors are a class of chemical compounds specifically designed to block the activity of sialyltransferase 7F (ST8SIA7), an enzyme involved in the transfer of sialic acid residues to glycoproteins and glycolipids. Sialyltransferases are essential in the process of sialylation, a post-translational modification where sialic acid is added to the terminal positions of glycan chains. This modification plays a critical role in cellular recognition, communication, and signaling. Sialyltransferase 7F, in particular, catalyzes the transfer of sialic acids to the terminal ends of N-linked or O-linked glycans on proteins and lipids. These modifications are crucial for regulating various biological processes, including cell adhesion, immune responses, and molecular stability. Inhibitors of sialyltransferase 7F are designed to interfere with this enzymatic activity, blocking the attachment of sialic acids to target glycans.
The design and development of sialyltransferase 7F inhibitors require a detailed understanding of the enzyme's catalytic site, where the transfer of sialic acid occurs. Structural biology techniques, such as X-ray crystallography, molecular docking, and computational modeling, are used to identify critical regions within the enzyme responsible for binding both the donor substrate (CMP-sialic acid) and the acceptor glycan. Inhibitors are designed to bind competitively to these active sites, preventing the enzyme from catalyzing the sialylation reaction. These inhibitors are assessed using biochemical assays to measure their binding affinity, specificity, and effectiveness in inhibiting sialyltransferase 7F activity. By studying these inhibitors, researchers can gain insights into the broader role of sialylation in cellular processes and the specific functions of sialyltransferase 7F in regulating glycan structure and function. This research enhances our understanding of how glycosylation affects cell biology and the importance of enzymes like sialyltransferase 7F in the post-translational modification landscape.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin may downregulate Sialyltransferase 7F by halting N-glycosylation, which is critical for maintaining the enzyme’s function and stability. Disruption of this process could lead to a decrease in the enzyme's synthesis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose could decrease the expression of Sialyltransferase 7F by competitively inhibiting glycolysis, leading to an energy deficit in the cell and reduced biosynthetic capacity for glycoenzyme synthesis. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
Kifunensine may cause the accumulation of immature glycoproteins, triggering the unfolded protein response that could subsequently decrease the expression levels of Sialyltransferase 7F due to cellular stress. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine could reduce Sialyltransferase 7F expression by inhibiting the processing of oligosaccharides on glycoproteins, potentially leading to glycoprotein trafficking defects and reduced expression of the enzyme. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine might decrease the expression of Sialyltransferase 7F by inhibiting glycosidase enzymes involved in the trimming of N-linked oligosaccharides, crucial for the proper folding of glycoproteins including glycosyltransferases. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin has the potential to inhibit glycosidase enzymes, leading to a buildup of misfolded glycoproteins which could trigger a cellular stress response, resulting in the downregulation of Sialyltransferase 7F expression. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Fostriecin could inhibit protein phosphatases, which might lead to altered phosphorylation states of transcription factors or co-factors involved in the expression of Sialyltransferase 7F, thus reducing its expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid has the potential to inhibit the expression of Sialyltransferase 7F by triggering apoptotic pathways and downregulating cellular processes associated with growth and metabolism, where this enzyme plays a role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059, by inhibiting MEK, could disrupt the MAPK/ERK signaling cascade, which may be crucial for the expression of genes coding for glycosylation enzymes, resulting in decreased levels of Sialyltransferase 7F. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 has the potential to inhibit p38 MAP kinase, leading to downregulation of stress response elements that may control the expression of Sialyltransferase 7F, leading to a decrease in its expression. | ||||||