Sialin inhibitors belong to a specific category of chemical compounds that play a significant role in the modulation of sialin, a transmembrane protein involved in the transport of sialic acid, a critical component of cell surface glycoproteins and glycolipids. Sialic acid serves several essential functions in biological systems, including cell adhesion, signal transduction, and the regulation of immune responses. The inhibition of sialin is primarily associated with its impact on the cellular transport of sialic acid. Sialin inhibitors are designed to interfere with the activity of sialin, thus influencing the cellular levels and distribution of sialic acid.
These inhibitors typically function by binding to sialin and disrupting its ability to facilitate the transport of sialic acid across cellular membranes. As a result, they can lead to alterations in sialic acid metabolism and distribution within the cell. The modulation of sialic acid levels can have far-reaching consequences, as it can impact various cellular processes and interactions. Sialin inhibitors have garnered attention in scientific research due to their potential to shed light on the fundamental mechanisms of sialic acid transport and metabolism within cells. Understanding the intricacies of sialin inhibition can provide valuable insights into the broader field of glycobiology, as sialic acid is a crucial component of glycosylation processes that influence cell function and communication. Researchers continue to explore the mechanisms and potential applications of sialin inhibitors in various biological contexts, making them a subject of ongoing investigation in the scientific community.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
AM 80, a synthetic retinoid, can modulate the expression of sialin indirectly through its action on gene transcription. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can alter transmembrane transport and may affect sialin's transporter function. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid inhibits various anion transporters and may influence the anion transport activity of sialin. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $102.00 | 20 | |
EIPA, an inhibitor of Na+/H+ exchange, can indirectly affect the cellular pH and thus sialin's transport efficiency. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 specifically inhibits V-ATPase, potentially altering vesicular pH and impacting sialin's role in vesicular acidification. | ||||||
Tenofovir | 147127-20-6 | sc-204335 sc-204335A | 10 mg 50 mg | $154.00 $633.00 | 11 | |
Tenofovir, an antiviral drug, can inhibit nucleotide/nucleoside transporters, potentially affecting sialin's function. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin can inhibit various purinergic receptors and transporters, which may indirectly alter sialin's function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises endosomal pH, which may influence sialin's role in pH-dependent transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can modulate various signaling pathways and may indirectly affect sialin's function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, can influence ion homeostasis and indirectly affect sialin's transport activity. | ||||||