Molecular structure of AM 80, CAS Number: 94497-51-5
AM 80 (CAS 94497-51-5)
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Alternate Names:
4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tet ramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid; Tamibarotene
Application:
AM 80 is a RARα agonist that induces differentiation and apoptosis
CAS Number:
94497-51-5
Purity:
>99%
Molecular Weight:
351.44
Molecular Formula:
C22H25NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Displays anticancer activity against acute promyelocytic leukemia in vivo and exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
AM 80 (CAS 94497-51-5) References
- Synthetic retinoids dissociate coactivator binding from corepressor release. | Zechel, C. 2002. J Recept Signal Transduct Res. 22: 31-61. PMID: 12503607
- International Union of Pharmacology. LX. Retinoic acid receptors. | Germain, P., et al. 2006. Pharmacol Rev. 58: 712-25. PMID: 17132850
- RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. | Jimi, S., et al. 2007. Int J Oncol. 31: 397-404. PMID: 17611697
- Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector. | Kamizono, A., et al. 1991. J Chromatogr. 567: 113-20. PMID: 1918238
- Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells. | VanGundy, ZC., et al. 2014. BMC Immunol. 15: 8. PMID: 24548459
- Tamibarotene modulates the local immune response in experimental periodontitis. | Jin, Y., et al. 2014. Int Immunopharmacol. 23: 537-45. PMID: 25448496
- Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. | Duprey-Díaz, MV., et al. 2016. PLoS One. 11: e0162626. PMID: 27611191
- A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy. | Watts, JM., et al. 2017. Int J Mol Sci. 18: PMID: 28696354
- A review of the molecular design and biological activities of RXR agonists. | de Almeida, NR. and Conda-Sheridan, M. 2019. Med Res Rev. 39: 1372-1397. PMID: 30941786
- Tamibarotene Improves Hippocampus Injury Induced by Focal Cerebral Ischemia-Reperfusion via Modulating PI3K/Akt Pathway in Rats. | Tian, X., et al. 2019. J Stroke Cerebrovasc Dis. 28: 1832-1840. PMID: 31078389
- Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. | Kagechika, H., et al. 1988. J Med Chem. 31: 2182-92. PMID: 3184125
- Retinoids in the Pathogenesis and Treatment of Liver Diseases. | Melis, M., et al. 2022. Nutrients. 14: PMID: 35406069
- Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome. | Zenkel, M., et al. 2022. Int J Mol Sci. 23: PMID: 35682657
Inhibitor of:
GREB1L, RARα1, RARα2, RXRβ2, and Sialin.Activator of:
CKR-9, CRABP-I, CRBP IV, GCM2, IRX2, RAI3, RAR alpha, RAR beta, RARα1, RARα2, Retinal RX, and robo2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AM 80, 10 mg | sc-203816 | 10 mg | $155.00 | |||
AM 80, 50 mg | sc-203816A | 50 mg | $620.00 |