SHKBP1 Inhibitors
The chemical class referred to asSHKBP1 Inhibitors principally centers on attenuating the Wnt signaling pathway in which SHKBP1 plays a role. These chemicals exploit various targets within the pathway to modify its signaling output. For instance, IWR-1-endo and XAV939 act by stabilizing Axin, thereby affecting the degradation of β-catenin, which is a pivotal factor in Wnt signaling. On the other hand, FH535 and JW55 modulate the action of both Wnt and PPAR signaling, providing a broader scope of inhibition that includes SHKBP1.
Inhibitors like PKF115-584, ICG-001, and CCT036477 directly focus on the β-catenin interactions that are crucial for Wnt pathway activation. These compounds inhibit β-catenin's interaction with TCF or CBP, which are essential for the downstream effects of Wnt signaling and thus for SHKBP1. Other compounds like LGK-974 and KY02111 target the enzymatic and receptor components of the Wnt pathway, respectively. In sum, these chemicals offer a targeted approach to attenuate the Wnt pathway and, consequently, the role of SHKBP1 in protein-protein interactions and signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo inhibits Wnt response by stabilizing Axin, a negative regulator in the Wnt pathway. This can indirectly suppress the role of SHKBP1, which is implicated in the same pathway. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
This compound inhibits tankyrase, leading to stabilization of Axin and thus attenuating Wnt signaling, affecting the functional context in which SHKBP1 operates. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
Inhibits both Wnt/β-catenin and PPAR signaling. By inhibiting Wnt signaling, it indirectly modulates the action of SHKBP1. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
Acts by inhibiting the interaction between β-catenin and coactivators. Given SHKBP1's role in Wnt signaling, this will indirectly inhibit its functional output. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
A Wnt signaling inhibitor that blocks β-catenin/TCF interaction. The inhibition of this interaction will indirectly inhibit SHKBP1 by limiting its scope of action. | ||||||
CCT036477 | 305372-78-5 | sc-391631A sc-391631 | 5 mg 25 mg | $109.00 $437.00 | 1 | |
An experimental Wnt inhibitor that can block the expression of Wnt target genes, thus indirectly affecting the role of SHKBP1 in Wnt signaling. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
This compound inhibits Porcupine, a membrane-bound O-acyltransferase, to attenuate Wnt signaling, indirectly affecting the action of SHKBP1. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 promotes the degradation of Wnt receptor, indirectly affecting the functional sphere in which SHKBP1 operates within Wnt signaling. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Affects Wnt signaling by influencing casein kinase 1α. This would indirectly modulate the action and importance of SHKBP1 within this signaling pathway. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
Inhibits the dimerization of the disheveled (Dvl) protein, impacting the Wnt signaling pathway and thus indirectly affecting SHKBP1. | ||||||