SHISA6 Activators
Shisa family member 6 activators encompass a variety of chemical compounds that interact with and influence distinct cellular signaling pathways, ultimately leading to the enhancement of the protein's functional activity. Forskolin operates through the elevation of cAMP levels, which stimulates PKA and can enhance the activity of shisa family member 6 by promoting phosphorylation at specific sites. Similarly, 8-Bromo-cAMP, a cAMP analog, bypasses upstream receptors and adenylyl cyclase to directly activate PKA, thus potentially enhancing shisa family member 6 activity. The protein kinase C pathway, modulated by compounds such as PMA and Bisindolylmaleimide I, playsa crucial role in cellular signaling, with PMA leading to PKC activation and subsequent phosphorylation of proteins that could include shisa family member 6. In contrast, Bisindolylmaleimide I inhibits PKC, which may result in a compensatory response that enhances shisa family member 6 activity through alternative pathways.
Calcium signaling is another pivotal pathway influencing shisa family member 6, where compounds like Calcium Ionophore A23187 and Bay K8644 increase intracellular calcium levels, thereby activating calcium-dependent proteins and pathways that could enhance shisa family member 6 activity. Similarly, Cyclopiazonic Acid, by inhibiting SERCA, raises cytosolic calcium, thereby initiating calcium-mediated signaling pathways. Okadaic Acid, by inhibiting protein phosphatases, leads to a hyperphosphorylated environment, which may indirectly enhance shisa family member 6 activity. Isoproterenol, through its beta-adrenergic receptor agonism, also elevates cAMP and activates PKA, promoting the phosphorylation of proteins, including potentially shisa family member 6. Certain biochemical modulators like Epigallocatechin Gallate (EGCG) inhibit phosphodiesterases, leading to sustained cAMP levels and PKA activation, which may indirectly enhance shisa family member 6 activity. KN-93's inhibition of CaMKII suggests a mechanism where the suppression of one pathway leads to the activation of complementary pathways that may enhance shisa family member 6 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP). Elevated cAMP levels enhance protein kinase A (PKA) activity, which can phosphorylate downstream targets and proteins, such as ion channels and transcription factors, that may include shisa family member 6, resulting in its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). The activation of PKC can lead to downstream effects, including changes in phosphorylation states of proteins. Through these means, PKC activation can enhance the activity of shisa family member 6 by altering its phosphorylation state. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. By inhibiting PKC, it can prevent the phosphorylation and thereby overactivation of certain substrates, which may lead to a compensatory upregulation or activation of alternative pathways that could enhance the activity of shisa family member 6. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This compound is a cell-permeable cAMP analog that directly activates cAMP-dependent pathways by bypassing the adenylyl cyclase activation step. The resulting activation of PKA can enhance shisa family member 6 activity through phosphorylation mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentrations, which can activate calcium-dependent proteins including PKC. The subsequent activation cascade can lead to the enhancement of shisa family member 6 activity through calcium-mediated signaling pathways. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid inhibits the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels. The rise in intracellular calcium can activate calcium-dependent signaling pathways, potentially enhancing the activity of shisa family member 6. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins within the cell. This hyperphosphorylated state can enhance shisa family member 6 activity as part of the cellular response to altered phosphorylation dynamics. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits the activity of certain phosphodiesterases, leading to increased cAMP levels within the cell. By elevating cAMP, EGCG can enhance PKA activity, which in turn may enhance the activity of shisa family member 6 via phosphorylation-dependent mechanisms. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that leads to the activation of adenylyl cyclase and increased cAMP production. The resultant PKA activation can enhance the activity of shisa family member 6 through cAMP-dependent phosphorylation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 acts as a calcium channel agonist, increasing calcium influx. The increased intracellular calcium can activate calcium-dependent signaling pathways, which may enhance the activity of shisa family member 6. | ||||||