SGK Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CGP 57380 | 522629-08-9 | sc-202993 | 5 mg | $172.00 | 6 | |
CGP 57380 is a distinctive SGK that showcases remarkable selectivity in its interactions with protein kinases, influencing downstream signaling pathways. Its unique structural features facilitate specific binding, leading to modulation of cellular processes. The compound's kinetic profile reveals a rapid association and dissociation with target proteins, allowing for dynamic regulation of enzymatic activity. This behavior underscores its potential in exploring intricate biochemical networks. | ||||||
GSK 650394 | 890842-28-1 | sc-361201 sc-361201A | 10 mg 50 mg | $183.00 $754.00 | 8 | |
GSK650394 is a specific inhibitor of SGK. It competes with ATP for binding to the kinase domain, thereby inhibiting SGK activity. | ||||||
CKI-7 dihydrochloride | 1177141-67-1 | sc-252621 sc-252621A | 5 mg 10 mg | $280.00 $320.00 | 5 | |
CKI-7 dihydrochloride is a notable SGK characterized by its ability to selectively inhibit specific serine/threonine kinases, thereby altering cellular signaling cascades. Its unique binding affinity is attributed to distinct molecular interactions that stabilize the kinase conformation. The compound exhibits a favorable kinetic profile, enabling swift modulation of target enzyme activity, which is crucial for dissecting complex regulatory mechanisms within cellular environments. | ||||||
SBI-0206965 | 1884220-36-3 | sc-507431 | 10 mg | $122.00 | ||
SBI-0206965 is a potent and selective SGK inhibitor. It competes with ATP for binding, thus inhibiting SGK1 kinase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Given that PI3K can activate SGK, inhibiting PI3K might down-regulate SGK1 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, and by inhibiting PI3K, it might down-regulate SGK1 activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Since mTOR can influence SGK activation, inhibiting mTOR might affect SGK1 function. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone, a mineralocorticoid receptor antagonist, might modulate SGK expression or activation in certain contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, can modulate multiple signaling pathways, potentially influencing SGK activation or expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and can modulate various signaling pathways, potentially affecting SGK function. | ||||||