SFMBT1 Activators
SFMBT1 activators are compounds known to modulate epigenetic marks and chromatin architecture. This modulation can, in turn, affect the expression and function of SFMBT1. Agents such as DNA methyltransferase inhibitors (5-Aza-2'-deoxycytidine, RG108) can lead to hypomethylation of DNA, potentially upregulating genes including those that encode SFMBT1 or influence its activity. The action of histone deacetylase inhibitors (Trichostatin A, Vorinostat, SAHA, Valproic acid) induces hyperacetylation of histone proteins, leading to a more relaxed chromatin state that could enhance the binding of SFMBT1 to chromatin and thus modify its activity.
Moreover, the interplay between SFMBT1 and its chromatin environment is influenced by the overall chromatin dynamics within the cell. Compounds that affect histone methylation (Methylstat) and acetylation (Disulfiram) can alter the recruitment and interaction patterns of chromatin-associated proteins, including SFMBT1. Modulators of gene expression such as Retinoic acid and Parthenolide also play a role in chromatin remodeling, which may alter the genomic regions SFMBT1 interacts with. Additionally, natural compounds with epigenetic impact like Genistein and EGCG have the capacity to influence DNA methylation and histone modification patterns, thereby indirectly affecting SFMBT1's functional landscape.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can lead to hypomethylation of DNA, potentially increasing SFMBT1 expression by altering the chromatin structure. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can result in a more open chromatin conformation, which may impact the recruitment and binding efficacy of SFMBT1 to chromatin. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor that, like Trichostatin A, can change chromatin architecture, possibly affecting SFMBT1 function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A short-chain fatty acid and HDAC inhibitor which may enhance the expression of genes encoding SFMBT1 or modulate its chromatin targets. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A that influences gene expression and can modify chromatin structure, potentially altering SFMBT1 activity. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
An inhibitor of histone methyltransferases that may change chromatin dynamics, thereby potentially influencing SFMBT1 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that may result in altered methylation patterns affecting SFMBT1 activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
A sesquiterpene lactone that can modify chromatin structure and potentially influence SFMBT1 activity indirectly. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An inhibitor of acetaldehyde dehydrogenase that has been shown to alter chromatin structure, which could impact SFMBT1 recruitment or stability. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that has been reported to inhibit DNA methyltransferase, potentially affecting the epigenetic regulation and hence SFMBT1 activity. | ||||||