SFMBT1 Antibody (FT-34): sc-135559
- SFMBT1 Antibody (FT-34) is a mouse monoclonal IgG2a κ SFMBT1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant SFMBT1 protein of human origin
- recommended for detection of SFMBT1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SFMBT1 Antibody (FT-34). This work is in progress.
SFMBT1 Antibody (FT-34) is a mouse monoclonal IgG2a kappa light chain antibody that detects SFMBT1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SFMBT1 antibody (FT-34) is available as a non-conjugated monoclonal isotype antibody. SFMBT1, also known as renal ubiquitous protein 1 (RU1), is an 866 amino acid protein characterized by high sequence similarity to the Drosophila scm protein, which serves as a transcriptional repressor crucial for Drosophila development. SFMBT1 is expressed across various cell lines and normal tissues, including the thymus, and predominantly localizes in the nucleus, where SFMBT1 plays a significant role in gene regulation. SFMBT1 features four MBT (Malignant Brain Tumor) repeats and one SAM (sterile alpha motif) domain, with the MBT motif being particularly important for recognizing methyl-lysine residues on histones, thereby influencing chromatin structure and function. As a member of the polycomb group proteins, SFMBT1 strongly associates with chromatin and functions as a transcriptional repressor, which is vital for maintaining cellular identity and regulating developmental processes. Two isoforms of SFMBT1 exist due to alternative splicing, further diversifying SFMBT1′s functional roles in cellular contexts.
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SFMBT1 Antibody (FT-34) References:
- Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. | Usui, H., et al. 2000. Gene. 248: 127-35. PMID: 10806358
- The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). | Boccuni, P., et al. 2003. J Biol Chem. 278: 15412-20. PMID: 12588862
- Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3. | Wu, S., et al. 2007. FEBS Lett. 581: 3289-96. PMID: 17599839
- Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. | Grimm, C., et al. 2007. EMBO Rep. 8: 1031-7. PMID: 17932512
- Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. | Guo, Y., et al. 2009. Nucleic Acids Res. 37: 2204-10. PMID: 19233876
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SFMBT1 Antibody (FT-34) | sc-135559 | 100 µg/ml | $339.00 |