SETBP1 Activators
SETBP1 activators are a category of chemical agents tailored to modulate the biological activity of the protein SET binding protein 1 (SETBP1). SETBP1 has gained interest in the scientific community due to its interaction with the SET protein, which itself is an inhibitor of protein phosphatase 2A (PP2A), an enzyme critical for various cellular functions. SETBP1 is thought to enhance the oncogenic potential of SET by protecting it from proteolytic degradation, thus maintaining its inhibitory effect on PP2A.
The mechanism of action of SETBP1 activators could be direct, such as binding to SETBP1 and inducing a conformational change that increases its ability to interact with and stabilize SET. These direct activators would thus potentiate the inhibitory effect of SET on PP2A, allowing for detailed studies on the downstream consequences of altered PP2A activity. Alternatively, direct activators may increase the affinity of SETBP1 for other molecular partners or substrates, impacting various signaling pathways and cellular processes. Indirect activators of SETBP1 may not interact with the protein directly but could increase its expression or stability within the cell. Such activators might function by promoting the transcription of the SETBP1 gene, by stabilizing its mRNA, or by inhibiting the pathways responsible for the protein's degradation. They might also involve the modulation of cellular signaling pathways that indirectly enhance the function of SETBP1, for example, by activating transcription factors that upregulate SETBP1 expression or by inhibiting negative regulatory mechanisms that would otherwise reduce SETBP1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is an HDAC inhibitor that can enhance the acetylation of histones, leading to changes in gene expression. This can indirectly enhance the functional activity of SETBP1, which is involved in chromatin remodeling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is another HDAC inhibitor. It can alter gene expression profiles in a way that can enhance the functional activity of SETBP1. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide can modulate the ubiquitin-proteasome system. Since SETBP1 is involved in protein-protein interactions, lenalidomide can influence its activity by modulating the abundance of its interacting partners. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that prevents the degradation of proteins. This can indirectly influence the functional activity of SETBP1 by altering the concentration of interacting proteins. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can alter DNA methylation profiles and gene expression. This can indirectly enhance the functional activity of SETBP1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is another DNA methyltransferase inhibitor that can modify gene expression profiles and indirectly enhance the functional activity of SETBP1. | ||||||
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $182.00 $1330.00 | 1 | |
Abexinostat is an HDAC inhibitor that can alter histone acetylation and gene expression, indirectly enhancing the functional activity of SETBP1. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor, which regulates gene expression by modifying chromatin structure. It can influence the cellular environment, thereby enhancing SETBP1's functional activity. | ||||||
AGI-6780 | 1432660-47-3 | sc-480257 | 2.5 mg | $330.00 | ||
UNC1999 is an inhibitor of EZH2, a histone methyltransferase. By altering histone methylation patterns and gene expression, UNC1999 can indirectly enhance the functional activity of SETBP1. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $90.00 $238.00 $300.00 | ||
GSK126 is another EZH2 inhibitor that can modify gene expression profiles, indirectly enhancing the functional activity of SETBP1. | ||||||