Molecular structure of PCI-24781, CAS Number: 783355-60-2
PCI-24781 (CAS 783355-60-2)
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Application:
PCI-24781 is an HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 inhibitor
CAS Number:
783355-60-2
Purity:
≥98%
Molecular Weight:
397.42
Molecular Formula:
C21H23N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PCI-24781 is a broad spectrum hydroxamic acid-based inhibitor of HDAC that shows antitumor activity in vitro. PCI-24781 inhibited pure recombinant HDAC1 with a Ki of 0.007 mumol/L, as well as HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range. Antitumor activity of PCI-24781 was observed in all 10 tumor cell lines tested, with GI50% values ranging from 0.15 to 3.09 mumol/L. PCI-24781 is an innovative inhibitor of histone deacetylases (HDACs), a class of enzymes responsible for epigenetic control of gene expression.
PCI-24781 (CAS 783355-60-2) References
- Radiosensitization by the histone deacetylase inhibitor PCI-24781. | Banuelos, CA., et al. 2007. Clin Cancer Res. 13: 6816-26. PMID: 18006784
- PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. | Bhalla, S., et al. 2009. Clin Cancer Res. 15: 3354-65. PMID: 19417023
- PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells. | Rivera-Del Valle, N., et al. 2010. Int J Cell Biol. 2010: 207420. PMID: 20145726
- Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells. | Yang, C., et al. 2011. Cancer Chemother Pharmacol. 67: 439-46. PMID: 20461381
- Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. | Yang, C., et al. 2011. Anticancer Res. 31: 1115-23. PMID: 21508354
- The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice. | Kitamura, T., et al. 2012. J Hepatol. 57: 84-91. PMID: 22326466
- RuvBL2 is involved in histone deacetylase inhibitor PCI-24781-induced cell death in SK-N-DZ neuroblastoma cells. | Zhan, Q., et al. 2013. PLoS One. 8: e71663. PMID: 23977108
- RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer. | He, WL., et al. 2014. World J Gastroenterol. 20: 10094-107. PMID: 25110436
- PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway. | Zhang, W., et al. 2014. Genet Mol Biol. 37: 716-24. PMID: 25505847
- PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma. | Sholler, GS., et al. 2013. J Cancer Ther Res. 2: 21. PMID: 25520806
- HDAC Inhibitors as Novel Anti-Cancer Therapeutics. | De Souza, C. and Chatterji, BP. 2015. Recent Pat Anticancer Drug Discov. 10: 145-62. PMID: 25782916
- The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines. | de Andrade, PV., et al. 2016. Cancer Cell Int. 16: 31. PMID: 27095947
- PCI-24781 can improve in vitro and in vivo developmental capacity of pig somatic cell nuclear transfer embryos. | Jin, L., et al. 2016. Biotechnol Lett. 38: 1433-41. PMID: 27271328
- The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer. | Yang, T., et al. 2021. Theranostics. 11: 2058-2076. PMID: 33500709
Inhibitor of:
ASF1B, DNHD1, HDAC, HDAC1, HDAC10, HDAC2, HDAC3, HDAC5, HDAC6, HDAC8, Histone H2A, Histone H3, MAGE-A9B, MOF, OTTMUSG00000010747, RP2, Rpd3, Sin3, TTC1, and V1RH18.Activator of:
H2BFA, MBD1, PABPC4, and SETBP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCI-24781, 5 mg | sc-364565 | 5 mg | $182.00 | |||
PCI-24781, 50 mg | sc-364565A | 50 mg | $1330.00 |