SerpinA3j Inhibitors
SerpinA3j, a member of the serine peptidase inhibitor clade A, is predicted to enable serine-type endopeptidase inhibitor activity and be involved in the negative regulation of endopeptidase activity. It is active in the extracellular space and has orthologs implicated in various diseases, including chronic obstructive pulmonary disease, cystic fibrosis, and vasculitis.
Inhibition of SerpinA3j involves direct and indirect mechanisms. Direct inhibitors, such as Alpha-1 Antitrypsin and Aprotinin, directly block its serine-type endopeptidase inhibitor activity, preventing the negative regulation of endopeptidase activity. Indirect inhibitors, like Camostat and Sivelestat, influence SerpinA3j by targeting proteases or modulating coagulation pathways, impacting its role in regulating endopeptidase activity. Understanding the intricate balance of serine protease regulation and the diverse mechanisms of inhibition provides insights into strategies targeting SerpinA3j in diseases associated with dysregulated proteolysis. The complex interplay between these inhibitors and SerpinA3j highlights the importance of maintaining protease-antiprotease balance in physiological and pathological conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Peptide protease inhibitor. Directly inhibits SerpinA3j by blocking its serine-type endopeptidase inhibitor activity, preventing negative regulation of endopeptidase activity. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
TMPRSS2 inhibitor. Indirectly influences SerpinA3j by preventing the activation of proteases such as TMPRSS2, potentially impacting its role in the negative regulation of endopeptidase activity. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Broad-spectrum serine protease inhibitor. Directly inhibits SerpinA3j's predicted serine-type endopeptidase inhibitor activity, affecting the regulation of endopeptidase activity. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
Endogenous protease inhibitor. Directly interacts with SerpinA3j, modulating its serine-type endopeptidase inhibitor activity and influencing negative regulation of endopeptidase activity. | ||||||
Sivelestat | 127373-66-4 | sc-203938 | 1 mg | $105.00 | 2 | |
Selective neutrophil elastase inhibitor. Indirectly affects SerpinA3j by modulating the activity of elastase, a target of SerpinA3j, potentially influencing the negative regulation of endopeptidase activity. | ||||||
PPACK dihydrochloride | 142036-63-3 | sc-201291 sc-201291A sc-201291B | 5 mg 25 mg 100 mg | $156.00 $572.00 $1775.00 | 26 | |
Thrombin inhibitor. Directly inhibits SerpinA3j by blocking thrombin activity, a target of SerpinA3j, affecting the regulation of endopeptidase activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Cysteine protease inhibitor. Indirectly influences SerpinA3j by inhibiting cysteine protease activity, potentially impacting its role in the negative regulation of endopeptidase activity. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
Broad-spectrum serine protease inhibitor. Directly inhibits SerpinA3j's predicted serine-type endopeptidase inhibitor activity, affecting the regulation of endopeptidase activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Serine protease inhibitor. Directly inhibits SerpinA3j's predicted serine-type endopeptidase inhibitor activity, affecting the regulation of endopeptidase activity. | ||||||