PPACK dihydrochloride CAS: 142036-63-3
MF: C21H31ClN6O3•2HCl
MW: 523.88
An irreversible, potent inhibitor of thrombin and its downstream effects.

PPACK dihydrochloride (CAS 142036-63-3)

PPACK dihydrochloride | CAS 142036-63-3 is rated 5.0 out of 5 by 3.
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Synonym: D-Phe-Pro-Arg-CMK; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-chloromethylketone
Application: An irreversible, potent inhibitor of thrombin and its downstream effects
CAS Number: 142036-63-3
Molecular Weight: 523.88
Molecular Formula: C21H31ClN6O32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PPACK is known to be an irreversible and potent inhibitor of thrombin, as well as prothrombin, shown to inhibit thrombin activation of progelatinase A. Additionally, pretreatment with PPACK has been shown to inhibit thrombin-induced cerebral thromboembolism.


References

1. Liu, J.T., et al. 1994. Eur. J. Pharmacol. 264: 183-190. PMID: 7851481
2. Rahr, H.B., et al. 1994. Thromb. Res. 73: 279-284. PMID: 8016814
3. Zucker, S., et al. 1995. J. Biol. Chem. 270: 23730-23738. PMID: 7559545
4. Kereiakes, D.J., et al. 2001. J. Thromb. Thrombolysis. 12: 123-127. PMID: 11729363

Physical State :
Solid
Solubility :
Soluble in water (0.3 mg/ml) at 25° C.
Storage :
Store at -20° C
Refractive Index :
n20D 1.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
13042154
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]@H](CC2=CC=CC=C2)N)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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PPACK dihydrochloride  Product Citations

See how others have used PPACK dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 30722079  Yu, X. et al. 2019. Thromb. Haemost. 119: 586-593.

PMID: # 30560697  Rigg, RA. et al. 2019. Platelets. 30: 126-135.

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 26725377  Zhu, S. et al. 2016. J. Thromb. Haemost. 14: 1070-81.

PMID: # 27816455  Streng, AS. et al. 2016. Biochem. Biophys. Res. Commun. 481: 165-168.

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

PMID: # 25094046  Wong, GW. et al. 2014. Biochem. Biophys. Res. Commun. 451: 314-8.

PMID: # 25264625  De Angelis, V. et al. 2014. PLoS ONE. 9: e108282.

PMID: # 22983162  Duong-Thi, MD. et al. 2013. Journal of biomolecular screening. 18: 160-71.

PMID: # 23479356  Duong-Thi, MD. et al. 2013. J Biomol Screen. 18: 748-55.

Citations 1 to 10 of 16 total

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, PPACK dihydrochloride (CAS 71142-71-7), ships on blue ice.
Answered by: Chemical Support 1
Date published: 2017-03-22
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Rated 5 out of 5 by from Great thrombin inhibitor We have been using PPACK from Santa Cruz for many years and it works very well.
Date published: 2020-01-24
Rated 5 out of 5 by from PPACK We used this thrombin inhibitor from Santa Cruz Biotechnology. It works well.
Date published: 2019-11-21
Rated 5 out of 5 by from Worked well for our lab Worked well for our lab.
Date published: 2015-06-10
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