Molecular structure of PPACK dihydrochloride, CAS Number: 142036-63-3
PPACK dihydrochloride (CAS 142036-63-3)
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Alternate Names:
PPACK dihydrochloride is also known as D-Phe-Pro-Arg-CMK.
Application:
PPACK dihydrochloride is an irreversible, potent, selective inhibitor of thrombin and its downstream effects.
CAS Number:
142036-63-3
Molecular Weight:
523.88
Molecular Formula:
C21H31ClN6O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PPACK dihydrochloride is recognized for its role in biochemistry and research applications, particularly those involving the study of enzymatic activity and reaction mechanisms. It is a potent inhibitor of serine proteases, a class of enzymes that play roles in various biological processes. By selectively binding to and inhibiting these enzymes, PPACK dihydrochloride allows researchers to explore the mechanisms of enzyme function, investigate the regulation of proteolytic pathways, and understand the underlying principles of enzyme inhibition. Its use contributes to the development of enzyme-based assays.
PPACK dihydrochloride (CAS 142036-63-3) References
- Differential effects of citrate versus PPACK anticoagulation on measured platelet inhibition by abciximab, eptifibatide and tirofiban. | Kereiakes, DJ., et al. 2001. J Thromb Thrombolysis. 12: 123-7. PMID: 11729363
- PPACK-thrombin is a noncompetitive inhibitor of alpha-thrombin binding to human platelets. | Schmaier, AH., et al. 1992. Thromb Res. 67: 479-89. PMID: 1448784
- Thrombin's enzymatic activity increases permeability of endothelial cell monolayers. | DeMichele, MA., et al. 1990. J Appl Physiol (1985). 69: 1599-606. PMID: 2272952
- PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change. | Greco, NJ., et al. 1990. Blood. 75: 1989-90. PMID: 2337670
- Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin. | Handley, LD., et al. 2015. Biochemistry. 54: 6650-8. PMID: 26468766
- Antithrombin nanoparticles inhibit stent thrombosis in ex vivo static and flow models. | Palekar, RU., et al. 2016. J Vasc Surg. 64: 1459-1467. PMID: 26482989
- Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis. | Zucker, S., et al. 1995. J Biol Chem. 270: 23730-8. PMID: 7559545
- D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. | Lyon, ME., et al. 1995. Clin Chem. 41: 1038-41. PMID: 7600685
- The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. | Vijayalakshmi, J., et al. 1994. Protein Sci. 3: 2254-71. PMID: 7756983
- Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK). | Rahr, HB., et al. 1994. Thromb Res. 73: 279-84. PMID: 8016814
- PPACK attenuates plasmin-induced changes in endothelial integrity. | Rabbani, LE., et al. 1993. Thromb Res. 70: 425-36. PMID: 8362368
- The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. | Yamashita, T., et al. 1993. Thromb Res. 69: 93-100. PMID: 8465278
- New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. | Martin, PD., et al. 1997. Structure. 5: 1681-93. PMID: 9438869
Inhibitor of:
Protease, Prothrombin, SerpinA3j, and Thrombin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPACK dihydrochloride, 5 mg | sc-201291 | 5 mg | $188.00 | |||
PPACK dihydrochloride, 25 mg | sc-201291A | 25 mg | $720.00 | |||
PPACK dihydrochloride, 100 mg | sc-201291B | 100 mg | $2500.00 |