SerpinA3j Activators
Serpina3j, classified within the serine peptidase inhibitor family, serves a crucial role in cellular homeostasis by actively engaging in the negative regulation of endopeptidase activity. This protein, predicted to be active in the extracellular space, plays a pivotal role in maintaining cellular proteostasis. Serpina3j is primarily involved in inhibiting serine-type endopeptidases, contributing to the prevention of uncontrolled proteolytic activities that could disrupt the delicate balance within cells.
The activation of Serpina3j involves intricate mechanisms orchestrated by various signaling pathways. These pathways, influenced by different chemical modulators, collectively contribute to the enhanced expression and functionality of Serpina3j. The activation mechanisms are diverse and interconnected, reflecting the complexity of cellular processes that Serpina3j influences. These activators may impact Serpina3j directly or indirectly, leading to an increased ability to inhibit endopeptidase activity. The intricate interplay of pathways, such as Nrf2, SIRT1, AMPK, PI3K/Akt, and MAPK, illustrates the multifaceted nature of Serpina3j activation. This complex network underscores the protein's crucial role in cellular protection, reinforcing its significance in maintaining the delicate equilibrium necessary for cellular resilience against proteolytic stress. Overall, Serpina3j stands as a key player in the cellular defense mechanism, actively working to preserve the integrity of cellular processes through the inhibition of endopeptidase activities.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, influences the Nrf2 pathway, leading to increased Serpina3j expression. This upregulation enhances the inhibition of endopeptidase activity, contributing to cellular homeostasis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, modulating the FOXO3a pathway. This indirect activation boosts Serpina3j expression, reinforcing its role in negative regulation of endopeptidase activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates AMPK, positively impacting Serpina3j through SIRT1-mediated pathways. This indirect activation strengthens the serine-type endopeptidase inhibitor activity, supporting cellular balance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, enhancing Serpina3j expression. This activation promotes the negative regulation of endopeptidase activity, contributing to cellular protection against proteolytic stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates Nrf2 and modulates MAPK pathways, leading to increased Serpina3j expression. This upregulation reinforces the serine-type endopeptidase inhibitor activity, supporting cellular proteostasis. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin activates Nrf2 and modulates PI3K/Akt pathways, enhancing Serpina3j expression. This indirect activation strengthens the inhibition of endopeptidase activity, contributing to cellular resilience. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates Nrf2 and modulates estrogen receptor signaling, positively influencing Serpina3j expression. This upregulation reinforces the serine-type endopeptidase inhibitor activity, supporting cellular equilibrium. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol activates Nrf2, promoting Serpina3j expression. This activation enhances the inhibition of endopeptidase activity, contributing to cellular protection against proteolytic stress. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin activates Nrf2 and modulates NF-κB pathways, leading to increased Serpina3j expression. This upregulation reinforces the serine-type endopeptidase inhibitor activity, supporting cellular homeostasis. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $78.00 | ||
Allyl disulfide activates Nrf2 and modulates PI3K/Akt pathways, positively influencing Serpina3j expression. This indirect activation strengthens the inhibition of endopeptidase activity, supporting cellular resilience. | ||||||