Septin 11 Activators
Septin 11 activators encompass a range of chemical compounds that facilitate the enhancement of Septin 11's functional activity within cellular signaling pathways. Forskolin, by boosting cAMP levels, indirectly activates PKA, a kinase that can phosphorylate proteins involved in cytoskeletal rearrangements, thereby reinforcing the essential role of Septin 11 in cellular division and vesicle transport. Similarly, PMA activates PKC, which phosphorylates substrates that influence cytoskeletal organization, promoting Septin 11's structural functions. The kinase inhibitor Epigallocatechin Gallate (EGCG) and PI3K inhibitors LY294002 and Wortmannin also play a significant role by altering signal transduction and cellular survival pathways, respectively, which can lead to a cellular environment that necessitates the enhanced involvement of Septin 11 in maintaining cytoskeletal integrity.
Further contributing to the activation of Septin 11 are compounds like U0126 and SB203580, which inhibit the MEK1/2 and p38 MAPK pathways, respectively. These inhibitors potentially cause a shift in cellular signaling to bolster pathways that require the participation of Septin 11 in cell division and structural organization. Additionally, the calcium ionophore A23187, by increasing intracellular calcium levels, activates calcium-dependent signaling pathways, thus amplifying Septin 11's role in various cellular processes. Moreover, lipid signaling modulators such as Sphingosine-1-phosphate and the SERCA pump inhibitor Thapsigargin elevate Septin 11's activity by modifying the signaling environment to favor cytoskeletal and membrane dynamics. Staurosporine, despite its broad kinase inhibition profile, may selectively elevate pathways that utilize Septin 11, enhancing its function in cytoskeletal and cellular division processes. Likewise, Genistein's inhibition of tyrosine kinases indirectly supports Septin 11's involvement in cytoskeletal organization, thus contributing to the collective enhancement of Septin 11's cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates various substrates, leading to the cytoskeletal rearrangements in which Septin 11 is crucial, thereby enhancing Septin 11's role in cell division and vesicle trafficking. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate a myriad of substrates including those that regulate the cytoskeleton. PKC activation can lead to the reorganization of cytoskeletal elements, thereby positively influencing Septin 11's function in cytoskeletal maintenance. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, primarily known as a kinase inhibitor, can modify signal transduction pathways. Its action on certain kinases can lead to altered cellular dynamics favoring the stabilization and function of cytoskeletal proteins, thus potentially enhancing the structural role of Septin 11. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that, by reducing PI3K activity, may shift cellular signaling dynamics to enhance the pathways involving cytoskeletal rearrangement and vesicle trafficking where Septin 11 is a key player. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that suppresses AKT phosphorylation leading to alterations in cell survival pathways. This can indirectly influence Septin 11's activity in cytoskeletal organization as cells adjust their structural components. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to a redirection of cellular signaling towards pathways that utilize Septin 11 for cytoskeletal organization and cell division. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways. This elevation can enhance the functional activity of Septin 11 by promoting its role in processes that depend on calcium signaling, such as vesicle trafficking and membrane dynamics. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that can influence actin cytoskeletal rearrangements. By altering the lipid signaling milieu, it can indirectly support the functional role of Septin 11 in cytoskeletal maintenance and cellular division. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels, indirectly supporting Septin 11's role in calcium-dependent cellular processes such as cytokinesis and vesicle trafficking. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor, which by inhibiting certain kinases may selectively enhance signaling pathways that utilize Septin 11, thereby augmenting its role in cytoskeletal dynamics and cell division. | ||||||