Sec24B Inhibitors
Chemical inhibitors of Sec24B can exert their inhibitory effects through various mechanisms impacting the cellular pathways in which this protein is involved. Exo1 inhibits Sar1, a GTPase essential for initiating COPII complex formation, and Sec24B's role in vesicle budding is contingent on the proper functioning of this complex. Thus, when Exo1 inhibits Sar1, it indirectly obstructs Sec24B's ability to participate in cargo selection for transport. Similarly, H89 targets protein kinase A and other related kinases, potentially altering the phosphorylation landscape of proteins that regulate or interact with Sec24B. This alteration could lead to the impairment of Sec24B's functionality in vesicle formation. Brefeldin A disrupts the Golgi apparatus by targeting ADP-ribosylation factor, a GTPase necessary for vesicle trafficking. This disruption has downstream effects on Sec24B, which is reliant on a functional Golgi for its role in vesicle trafficking.
In addition, ML9's inhibition of myosin light chain kinase can lead to cytoskeletal changes that affect Sec24B's vesicle transport capabilities. Gö6976, through its selective inhibition of certain protein kinase C isoforms, can alter the phosphorylation state of proteins involved in vesicle trafficking, leading to an indirect inhibition of Sec24B's function. Wortmannin, by inhibiting phosphoinositide 3-kinases, affects the production of necessary phosphoinositides for vesicle formation in which Sec24B takes part. Dynasore targets dynamin GTPase activity, preventing vesicle scission from the Golgi, consequently hindering the release of Sec24B-containing COPII vesicles. Furthermore, Latrunculin A and Jasplakinolide disrupt normal actin dynamics, which is critical for Sec24B's function in vesicle trafficking; Latrunculin A by inhibiting actin polymerization, and Jasplakinolide by stabilizing actin filaments, thereby impeding vesicle transport. CK-636 impedes Sec24B by targeting the Arp2/3 complex, which is responsible for actin nucleation and thus vital for Sec24B's role in vesicle formation and movement. Pitstop 2 inhibits clathrin-mediated endocytosis, which can indirectly influence Sec24B's function in sorting and transporting cargo. Lastly, YM-201636's inhibition of phosphatidylinositol 4-kinase III beta impacts the generation of PI4P, a lipid that orchestrates vesicle-mediated transport, thereby indirectly inhibiting Sec24B's participation in vesicle formation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 3 | |
Exo1 specifically inhibits Sar1, a GTPase that acts upstream in the COPII complex formation, which is critical for vesicle budding from the endoplasmic reticulum. By inhibiting Sar1, Exo1 indirectly prevents the recruitment of Sec24B to the COPII vesicle formation sites, thereby inhibiting its function in cargo selection. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H89 is a protein kinase A inhibitor that can also affect other kinases. By inhibiting general phosphorylation events within the cell, H89 can indirectly inhibit the phosphorylation state of proteins that interact with or regulate Sec24B, thus impeding its function in vesicle formation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus by inhibiting ADP-ribosylation factor (Arf), a small GTPase involved in vesicle formation. Since Sec24B function is reliant on proper Golgi apparatus structure for vesicle trafficking, Brefeldin A indirectly inhibits Sec24B by disrupting upstream processes required for its action. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML9 is an inhibitor of myosin light chain kinase (MLCK), which plays a role in cytoskeletal dynamics. Given that Sec24B is involved in vesicle trafficking, the inhibition of MLCK can lead to cytoskeletal changes that indirectly inhibit Sec24B's ability to properly traffic vesicles. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 is a selective inhibitor of protein kinase C (PKC) isoforms. Since PKC can phosphorylate multiple targets involved in vesicle trafficking, the inhibition of PKC by Gö6976 can result in an indirect inhibition of Sec24B by altering the phosphorylation state of proteins that guide vesicle formation and release, where Sec24B has a role. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, wortmannin can affect the production of phosphoinositides that are required for proper vesicle formation and trafficking, processes in which Sec24B is integral, therefore indirectly inhibiting Sec24B's function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a small molecule inhibitor of the GTPase activity of dynamin, which is involved in vesicle scission from the Golgi. Inhibiting dynamin's function can indirectly inhibit Sec24B by preventing the release of COPII vesicles, which Sec24B helps to form. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A disrupts actin polymerization, which is involved in providing the structural framework necessary for vesicle trafficking. An indirect inhibition of Sec24B can occur due to compromised actin dynamics, impeding the transport of vesicles that Sec24B is a part of. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can lead to the disruption of normal cytoskeletal dynamics. This stabilization can indirectly inhibit Sec24B by impairing the vesicle transport processes it is involved in. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. By inhibiting clathrin, it indirectly affects vesicle formation and trafficking, processes that are essential for the proper functioning of Sec24B in cargo selection and transport. | ||||||