Molecular structure of Exo1, CAS Number: 461681-88-9
Exo1 (CAS 461681-88-9)
See product citations (4)
Alternate Names:
EXOCYTIC INHIBITOR 1;2-[(4-Fluorobenzoyl)amino]benzoic acid methyl ester
Application:
Exo1 is an inhibitor of protein traffic emanating from the ER which acts by inducing the fast collapse of the Golgi
CAS Number:
461681-88-9
Purity:
≥98%
Molecular Weight:
273.26
Molecular Formula:
C15H12FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Exo1 is a compound which disrupts the functions of the Golgi apparatus by causing a fast collapse of the organelle. It is known that the Golgi functions to package proteins in order to prepare them from secretion. Exo1 can disrupt this function by releasing ARF1 (ADP-ribosylation factor 1) from membranes of the Golgi. In addition, Exo1 can be an essential tool in differentiating between Bars50 and ARF1 fatty acid exchange activity as a result of the lack of interaction between Exo1 and guanine nucleotide exchange factors. Furthermore, Exo1 reduces the traffic of proteins emanating from the endoplasmic reticulum.
Exo1 (CAS 461681-88-9) References
- Exo1: a new chemical inhibitor of the exocytic pathway. | Feng, Y., et al. 2003. Proc Natl Acad Sci U S A. 100: 6469-74. PMID: 12738886
- Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. | Bolderson, E., et al. 2010. Nucleic Acids Res. 38: 1821-31. PMID: 20019063
- Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. | Ryu, SY., et al. 2010. Cell Calcium. 47: 65-76. PMID: 20022109
- Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan. | Bau, DT., et al. 2009. Chin J Physiol. 52: 411-8. PMID: 20337148
- SIGN-R1, a C-type lectin, binds to Bip/GRP78 and this interaction mediates the regurgitation of T-cell-independent type 2 antigen dextran through the endoplasmic reticulum. | Choi, HJ., et al. 2011. Immunobiology. 216: 437-46. PMID: 20951467
- Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids. | Lu, H., et al. 2015. Biomater Sci. 3: 1085-95. PMID: 26221942
- XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. | Greene, DL., et al. 2017. J Pharmacol Exp Ther. 362: 177-185. PMID: 28483800
- Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer. | Ding, L., et al. 2022. ACS Appl Mater Interfaces. 14: 10015-10029. PMID: 35188730
Inhibitor of:
β′-COP, 2410002O22Rik, ACAP2, AP1S2_Ap1s2, AP1S3, ARFGAP3, ARL11, ARRDC5, ART1, BC006779, BET5, CAPS-1, CAPS2, CCDC115, CCPG1, COG3, COPZ2, CTAGE6, D030016E14Rik, DENND2C, DENND4C, DENND6B, EG433102, Epsilon-COP, Exocyst complex component (EXOC), GBF1, GOLGA8R, GOLGB1, Golgin 45, Herc4, HRASLS5, Intersectin-2, LLGL4, MIA2, PACS-1b, Peroxin 10, Rab 27a, Rabaptin-5β, SAA2, Sar1, Sar1a, Sar1B, SCAMP5, SCFD2, SDF-4, Sec1, Sec15B, SEC16A, SEC16S, SEC22A, Sec24, Sec24B, Sec24C, Sec31B, SPCS2, Syntaxin 11, Syntaxin 12, Syntaxin 1A, TBC1D19, TBC1D25, TGN38B, TIP20, TIP47, TMED1, TMED4, TMED8, TMX3, TRAPPC2L, TRAPPC5, TRIM44, VEPH1, VPS51, YIF1A, YIPF3, YJEFN3, and ZNRF2.Activator of:
D030016E14Rik, D030074E01Rik, EG433102, GCC2, golgin 97, and Sec24D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exo1, 10 mg | sc-200752 | 10 mg | $84.00 | |||
Exo1, 50 mg | sc-200752A | 50 mg | $297.00 |